ArticleInternational journal of clinical and experimental pathology2017
Changes in the expression of Col IV, gelatinase and TIMP-1 in oral leukoplakia.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- The Inflammatory-Dysplastic Spectrum in Oral Lichen Planus: A Study on Six Immunohistochemical Markers.Diagnostics (Basel, Switzerland) · 2025Article
- New insights into the role of the oral leukoplakia microenvironment in malignant transformation.Frontiers in oral health · 2024Review
- Transcriptomic analysis predicts the risk of progression of premalignant lesions in human tongue.Discover oncology · 2023Article
- Review
- Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer.Cancers · 2021Review
- Matrix metalloproteinase-9 expression in oral potentially malignant disorders and oral squamous cell carcinoma - An immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type IV collagen (Col IV) is an important protein in the basement membrane (BM), which can regulate the attachment of epithelium and the lamina propria. To test the hypothesis that Col IV may play a significant role in the progression of oral leukoplakia, we have observed the morphology and distribution of Col IV in 40 patients with oral leukoplakia (epithelial hyperplasia and dysplasia). The results showed that the expression of Col IV in the BM was continuous in normal oral mucosa, while it was non-continuous or fragmented in epithelial dysplasia by immunofluorescent staining. Consequently, to analyze the correlated factors of the Col IV destruction, the expressions of gelatinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinases -1 (TIMP-1) were detected in oral leukoplakia tissues by immunochemical staining. Then statistical analyses were performed to determine their correlations with Col IV levels. The statistics showed that the decreasing of Col IV was closely related to the increasing of MMP-9 in both epithelial hyperplasia and dysplasia (
Indexed as
Identifiers
31966707PMC6965367W3028066345What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.