ArticleInternational journal of clinical and experimental pathology2017
Bone morphogenetic protein 7 alleviates paraquat-induced pulmonary fibrosis via TGF-β1/Erk1/2 pathway.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF-β Signaling Pathways.Inflammation · 2022Article
- Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic protein 7 (BMP-7) recently demonstrates an anti-fibrotic effect. To evaluate the role of BMP-7 in paraquat (PQ)-induced pulmonary fibrosis, PQ-exposed mice and lung fibroblasts (MRC-5) were treated with BMP-7. Our results showed that BMP-7 treatment could significantly reduce PQ-induced pulmonary fibrosis, accompanied by downregulation of transforming growth factor (TGF)-β1 and collagen I deposition in mouse lungs. Moreover, PQ-induced inviability, apoptosis, high level of collagen I, as well as phosphorylation of Erk1/2, in MRC-5 cells were significantly inhibited by BMP-7 treatment. These findings indicate BMP-7 alleviates PQ-induced pulmonary fibrosis partly via TGF-β1/Erk1/2 pathway, suggesting a promising therapeutic means for PQ-induced fibrotic lung injury.
Indexed as
Identifiers
31966703PMC6965432W3013718746What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.