ArticleInternational journal of clinical and experimental pathology2017
Silence of Beclin1 in oral squamous cell carcinoma cells promotes proliferation, inhibits apoptosis, and enhances chemosensitivity.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Targeting autophagy in oral squamous cell carcinoma chemoresistance: molecular mechanisms, therapeutic strategies, and emerging nanotherapeutic approaches.Molecular biology reports · 2026Review
- Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK.International journal of oral science · 2024Article
- Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions.Frontiers in oncology · 2022Review
- Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma.Cancers · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence indicates that autophagy plays an important role in regulating proliferation and apoptosis in several human diseases, including cancer. Beclin1 is the first tumor-suppressor gene in mammals involved in the regulation of autophagy. However, the function of Beclin1 in oral cancer cells is not clear at present. We investigated the effects of Beclin1 on the biological characteristics of oral carcinoma cells by Small interfering RNA (siRNA) technology. We found that Beclin1 silencing promoted proliferation, migration, and invasion of oral squamous cell carcinoma cells, and inhibited apoptosis primarily associated with upregulation of survivin and bcl-2. Further, Beclin1 silencing enhanced chemosensitivity to cisplatin. Thus, the Beclin1 gene is expected to become a new therapeutic target for oral cancer.
Indexed as
Identifiers
31966694PMC6965406W3012774468What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.