Evidence map›Paper›PMID 31966690›Full record

ArticleInternational journal of clinical and experimental pathology2017

Circulating exosomes and exosomal lncRNA HIF1A-AS1 in atherosclerosis.

Yingge Wang, Jingyan Liang, Jiang Xu, Xiaohong Wang, Xinjiang Zhang, Weiguang Wang, Lu Chen, Tingting Yuan

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Emerging Roles of Long Non-Coding RNAs in Cardiovascular Diseases.Journal of cellular and molecular medicine · 2025
    Review
  4. Observational
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  7. Review
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  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. New Developments in Exosomal lncRNAs in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021
    Review
  20. Exosomes in Cardiovascular Diseases.Diagnostics (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yingge WangDepartment of Anatomy, Medical College, Yangzhou University Yangzhou, China.
Jingyan LiangDepartment of Anatomy, Medical College, Yangzhou University Yangzhou, China.
Jiang XuResearch Center for Vascular Biology, Medical College, Yangzhou University Yangzhou, China.
Xiaohong WangDepartment of Anatomy, Medical College, Yangzhou University Yangzhou, China.
Xinjiang ZhangAffiliated Hospital of Yangzhou University Yangzhou, China.
Weiguang WangDepartment of Hematology, First Affiliated Hospital of Jiamusi University Jiamusi, China.
Lu ChenDepartment of Anatomy, Medical College, Yangzhou University Yangzhou, China.
Tingting YuanDepartment of Anatomy, Medical College, Yangzhou University Yangzhou, China.
Northern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExosomes which mainly function in intercellular communication and lncRNA HIF1A-AS1 which can be transferred by exosomes, have been shown to play a significant role in atherosclerosis. This study aims to explore the diagnostic value of exosomes and exosomal lncRNA HIF in atherosclerosis.

methodsPlasma sample from 35 patients with atherosclerosis and from 28 healthy adults were collected for further investigation. The exosomes were extracted from the plasma sample and then the concentration of exosomes was measured by flow cytometry. Then the exosomal RNA was isolated and exosomal lncRNA HIF1A-AS1 was quantified using real-time polymerase chain reaction (qRT-PCR). Finally, the concentration of exosomes and the expression level of exosomal lncRNA HIF1A-AS1 were analyzed using Spearman's correlation test, and receiver operating characteristic (ROC) curves were used for evaluation of diagnostic accuracy of exosomes and exosomal lncRNA HIF1A-AS1.

resultsThe concentration of exosomes was significantly higher in patients with atherosclerosis than that in healthy people, the same as the expression level of exosomal lncRNA HIF1A-AS1. Furthermore, the result of Spearman's correlation test indicated that there was a positive correlation between them. Last, we also showed that the area values under the ROC curves of exosomes and lncRNA HIF1A-AS1 were 0.856 and 0.823, respectively.

conclusionExosomes and exosomal lncRNA HIF1A-AS1 could act as potential biomarkers for atherosclerosis.

Indexed as

atherosclerosisbiomarkerExosomal lncRNAHIF1A-AS1

Identifiers

PMID31966690
PMCPMC6965439
OpenAlexW3008953708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.