ArticleInternational journal of clinical and experimental pathology2017
Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 in severe
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.Malaria journal · 2026Pooled it
- Article
- Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment.Frontiers in cellular and infection microbiology · 2022Article
- Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis.International journal of molecular sciences · 2021Article
- Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections.International journal of molecular sciences · 2021Review
- Novel kidney injury biomarkers in tropical infections: a review of the literature.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Review
- Expression of 4-Hydroxynonenal (4-HNE) and Heme Oxygenase-1 (HO-1) in the Kidneys ofJournal of tropical medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney injury molecule-1 (KIM-1) is a specific histological biomarker for diagnosing early acute kidney injury which is markedly up-regulated in the proximal tubular cells in acute and chronic tubular injury. KIM-1 expression is poorly defined in the renal tubules of malaria patients. This present study aimed to determine KIM-1 expression as a specific biomarker for acute tubular damage and to identify matrix metalloproteinase-3 (MMP-3) as a mediator for KIM-1 shedding. Paraffin-embedded kidney tissues from autopsies of malaria patients were obtained from the Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Thailand. The kidney tissues were divided into 2 groups: those with acute kidney injury (AKI) (n = 10 cases) and those with non-AKI (n = 10 cases). Ten normal kidney tissues were used as a control group. The expression of KIM-1 and MMP-3 was examined by immunohistochemical staining. KIM-1 and MMP-3 expressions were strongly expressed in the proximal tubular cells in all kidney tissues from severe
Indexed as
Identifiers
31966633PMC6965263W3009333829What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.