ArticleInternational journal of clinical and experimental pathology2017
Elevated expression of importin 8 in inflamed human dental pulps.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Wnt4 prevents apoptosis and inflammation of dental pulp cells induced by LPS by inhibiting the IKK/NF‑κB pathway.Experimental and therapeutic medicine · 2023Article
- Importin 8 is involved in human periodontitis by the NF-κB pathway.International journal of clinical and experimental pathology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was to elucidate the roles of importin 8 in human dental pulp inflammatory activity by quantifying importin 8 expression in healthy and inflamed human dental pulps. 30 human dental pulps suffering from irreversible pulpitis caused by carious were involved in the study. The expression of IPO8 was detected by immunohistochemistry, immunofluorescence, Real-time PCR and Western blot respectively. NF-κB p p65 and p IκBα expressions in nuclear protein of dental pulps were detected to investigate NF-κB activation. Our results showed that IPO8 expression in inflamed human dental pulps increased significantly at both mRNA and protein levels compared with healthy pulps. In healthy pulps, the positive expression of IPO8 was mainly in odontoblasts. Under inflammatory conditions, IPO8 staining was also observed in nerve fiber tissues and dilated blood vessels, besides odontoblasts. NF-κB 65 and IκBα phosphorylation in cell nuclei was significantly upregulated in inflamed human dental pulps. In conclusion, IPO8 may be a marker reflecting human dental pulp inflammation. NF-κB is activated in human pulp inflammatory activity.
Indexed as
Identifiers
31966616PMC6965251W3026984962What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.