ArticleInternational journal of clinical and experimental pathology2017
The regulatory role of Mcl-1 in apoptosis of mouse peritoneal macrophage infected with
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Regulatory role and mechanism of the inhibition of the Mcl-1 pathway during apoptosis and polarization of H37Rv-infected macrophages.Medicine · 2020Article
- Article
- Mcl-1 signals pathway inhibitors in mouse peritoneal macrophage apoptosis infected with the Xinjiang strain ofInternational journal of clinical and experimental pathology · 2017Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMyeloid cell leukaemia-1 (Mcl-1) is a valuable target in tumour treatments. However, several reports have suggested that Mcl-1 may play a role in tuberculosis infection. Therefore, we investigated the function of Mcl-1 in tuberculosis infection and the underlying regulatory mechanism.
methodsMcl-1-shRNA was used to down-regulate Mcl-1 expression in BCG-, H37Ra-, H37Rv- and XJ-MTB-infected mouse peritoneal macrophages. TUNEL staining detected macrophage apoptosis. The colony-forming units (CFUs) were determined to assess the
resultsMcl-1-shRNA significantly promoted host macrophage apoptosis and cytochrome-c induction, and the apoptotic induction of the XJ-MTB and H37Rv strains was stronger than the H37Ra and BCG strains (
conclusionMcl-1-shRNA intervention effectively down-regulated Mcl-1 expression, significantly increased host macrophage apoptosis, and induced cytochrome-c expression in mouse peritoneal macrophages infected with MTB strains of different virulence, and these changes were influenced by the virulence of the MTB strains. The mitochondria-mediated intrinsic apoptotic pathway play an important role before Mcl-1-shRNA-trated, and then with the extrinsic apoptotic pathway co-regulate host macrophage apoptosis.
Indexed as
Identifiers
31966601PMC6965215W3010094896What OpenQuestion holds
Registered trials
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