Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.

Chengcheng Liu, Tingting Tao, Lei Zhao, Yi Ding

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Drug-Induced Gingival Overgrowth: The Effect of Cyclosporin A and Mycophenolate Mophetil on Human Gingival Fibroblasts.Biomedicines · 2020
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chengcheng LiuState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, PR China.

Tingting TaoState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, PR China.

Lei ZhaoState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, PR China.

Yi DingState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, PR China.

Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGeneralized gingival fibromatosis is characterized by a progressive overgrowth of the gingiva, which can be caused by a variety of factors. According to these factors, it can be defined as hereditary gingival fibromatosis, non-familial gingival fibromatosis or drug-induced gingival fibromatosis. Non-familial gingival fibromatosis is a rare entity that needs to be documented. CASE PRESENTATION: Here, we describe two cases of Chinese non-familial gingival fibromatosis. A six-year-old girl and a five-year-old boy presented with generalized gingival overgrowth. Clinical appearance, histological examination, and family history lead to the diagnosis of non-familial gingival fibromatosis. Real time PCR was performed to examine the expression of the α2-integrin gene,

conclusionOur findings provide evidence that altered cell-matrix interactions via collagen receptors, such as α2-integrin, may play a role in non-familial gingival fibromatosis. Thus, targeting collagen receptors might be an attractive target for the treatment of gingival fibromatosis.

Indexed as

fibroblast phagocytosisGingival fibromatosisα2-integrin

Identifiers

PMID31966593

PMCPMC6965286

OpenAlexW3027032883

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.