ArticleInternational journal of clinical and experimental pathology2017
IL-8 -251A/T and +781C/T polymorphisms were associated with risk of breast cancer in a Chinese population.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer.Cancer reports (Hoboken, N.J.) · 2025Article
- Article
- Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the leading cause of death of women in worldwide. The real mechanism of breast cancer is still unclear. IL-8 is a member of the chemokine superfamily, which plays an important role in regulating both inflammatory and immune processes. We performed a hospital-based case-control study to estimate the association between IL-8 -251A/T, -353A/T and +781C/T polymorphisms and risk of breast cancer in a Chinese population, and interaction between IL-8 polymorphism and environmental factors. During January 2014 and July 2016, a total of 442 patients with breast cancer and 447 normal control subjects were enrolled into our study. The IL-8 -251A/T, -353A/T and +781C/T polymorphisms were analyzed by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). The TT genotype of IL-8 -251A/T was associated with higher risk of breast cancer as compared with the AA genotype (adjusted OR=1.96, 95% CI=1.26-3.05). Individuals carrying TT genotype of IL-8 -251A/T was correlated with an elevated risk of breast cancer in recessive model, when compared with the AA+AT genotype (adjusted OR=1.91, 95% CI=1.26-2.90). For the IL-8 +781C/T, the TT genotype showed lower association with risk of breast cancer in comparison to the CC genotype (adjusted OR=0.49, 95% CI=0.26-0.91); the TT genotype was also correlated with a decreased risk of breast cancer in recessive model (adjusted OR=0.46, 95% CI=0.25-0.84), as compared with the CC+CT genotype. In conclusion, our study suggests that IL-8 -251A/T and +781C/T could potentially be a biomarker for susceptibility to breast cancer risk.
Indexed as
Identifiers
31966587PMC6965227W3027777362What OpenQuestion holds
Registered trials
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