Evidence map›Paper›PMID 31966585›Full record

ArticleInternational journal of clinical and experimental pathology2017

Characterization and functional elucidation of CD8+AT2+ lymphocytes in human thoracic aortic aneurysm.

Chenxi Wang, Weijun Wang, Mingjun Du, Xinyu Liu, Song Xue

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Angiotensin ATPharmacological reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chenxi WangDepartment of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Weijun WangDepartment of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Mingjun DuDepartment of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Xinyu LiuDepartment of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Song XueDepartment of Cardiovascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.
Renji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human thoracic aortic aneurysm (TAA) is one of the most fatal cardiovascular diseases. However, the underlying molecular mechanism behind this disease remains uncertain. Previous studies have proven the importance of angiotensin II receptor type 2 (AT2) and endothelial cells in aneurysm pathology. This study aimed to elucidate the effect of CD8+AT2+ lymphocytes in TAA pathogenesis. The expression levels of CD8, AT2, IL-2, and IFN-r were determined by real-time quantitative PCR. CD8+AT2+ lymphocytes were counted by semi-quantitative immunofluorescence and flow cytometric analysis. The wound-healing assay was used to detect endothelial cell migration. The expression levels of CD8 and AT2 in human nonsyndromic TAA tissues were significantly higher than those of the control. TAA tissues have more CD8+AT2+ lymphocytes than the controls. Furthermore, circulating CD8+AT2+ lymphocytes were significantly elevated in TAA patients. The expression levels of IL-2 and IFN-r in CD8+AT2+ lymphocytes were significantly increased compared with those in CD8+AT2- lymphocytes. The CD8+AT2+ lymphocytes had a greater inhibitory effect on endothelial migration compared with CD8+AT2- cells. Our findings showed that the increment of CD8+AT2+ lymphocytes in human TAA exhibited a protective effect by downregulating the release of pro-inflammation cytokines and the inhibition of endothelial cell migration.

Indexed as

Angiotensin II type 2 receptorcytokineendothelial cellinflammationthoracic aortic aneurysm

Identifiers

PMID31966585
PMCPMC6965229
OpenAlexW3008165038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.