Evidence map›Paper›PMID 31966578›Full record

ArticleInternational journal of clinical and experimental pathology2017

Qian Chen, Rongliang Shi, Daowen Jiang, Weiyan Liu, Zhenyi Jia

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  7. A novel anticancer property ofJournal of Zhejiang University. Science. B · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qian ChenDepartment of General Surgery, Minhang Hospital, Fudan University China.
Rongliang ShiDepartment of General Surgery, Minhang Hospital, Fudan University China.
Daowen JiangDepartment of General Surgery, Minhang Hospital, Fudan University China.
Weiyan LiuDepartment of General Surgery, Minhang Hospital, Fudan University China.
Zhenyi JiaDepartment of General Surgery, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University China.
Obstetrics and Gynecology Hospital of Fudan University · CNShanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of

methodsHuman GC SGC-7901 cells were divided into control, 10 μM LBP, 20 μM LBP and 50 μM LBP groups. CCK8 assay and Transwell assay were performed to evaluate the proliferation, migration and invasion of SGC-7901 cells. Western blotting was used to determine protein expressions.

resultsThe proliferation, migration and invasion decreased significantly in 20 μM LBP and 50 μM LBP groups. As the result of Western blotting, protein levels of MMP2, MMP9, Snail and vimentin decreased in 20 μM LBP and 50 μM LBP groups with different degrees. The expression E-cadherin significantly increased in all three experimental groups. The phosphorylation levels of AKT and PI3K in 20 μM LBP and 50 μM LBP groups were much lower than control group.

conclusionLBP could inhibit the proliferation, migration and invasion of human GC cells bydown-regulation of MMPs and suppression of epithelial-mesenchymal transition (EMT).

Indexed as

epithelial-mesenchymal transitiongastric cancerLycium barbarum polysaccharideMMPs

Identifiers

PMID31966578
PMCPMC6965242
OpenAlexW3026671215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.