Evidence map›Paper›PMID 31966537›Full record

ArticleInternational journal of clinical and experimental pathology2017

Prevalence of programmed death-1 ligand-1 (PD-L1) and infiltrating lymphocytes in human gastric carcinogenesis.

Zhonghua Liu, Yufang Wang, Xiaolei Luo, Yanyun Wang, Lin Zhang, Tao Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhonghua LiuDepartment of Geriatrics, No. 4 West China Teaching Hospital, Sichuan University Chengdu, Sichuan, P.R. China.
Yufang WangDepartment of Pathophysiology, School of Preclinical and Forensic Medicine, Sichuan University Chengdu, Sichuan, P.R. China.
Xiaolei LuoLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, P.R. China.
Yanyun WangLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, P.R. China.
Lin ZhangLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, P.R. China.
Tao WangLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu, Sichuan, P.R. China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe PD-1/PD-L1 pathway plays a key role in the immune evasion of tumor cells from the host immune system. This study aimed to examine PD-L1 expression and prevalence of infiltrating T cellin gastric diseases, and elucidate the relevance of PD-L1 and prevalence of infiltrating T cell in the pathogenesis of gastric carcinoma.

methodsImmunohistochemistry and HE staining were used to investigate the

resultsThe expression of PD-L1 was found to be most prevalent in gastric carcinoma and, by comparison, decreased in gastric tissues from patients with gastric ulcer or intestinal metaplasia/atrophic gastritis. The overexpression of PD-L1 was notably more prevalent in cancer tissues and tissues from cases of intestinal metaplasia/atrophic gastritis, with the highest prevalence observed in intestinal metaplasia/atrophic gastritis. Meanwhile, decreasing prevalence was observed for CD4 and CD8 expression in gastric carcinoma. Therefore, PD-L1 expression in gastric carcinoma appeared to be inversely correlated with prevalence of infiltrating T cell.

conclusionPD-L1 expression was more prevalent while CD4 and CD8 expression were decreased in gastric carcinoma compared with gastric ulcer and intestinal metaplasia/atrophic gastritis. As the activated immunological status in gastric ulcerappears to switch to one of immunological suppression in intestinal metaplasia/atrophic gastritis and gastric carcinoma, this may suggest that the immune evasion associated with the PD-L1 pathway may be triggered in the pathogenesis of human gastric carcinoma.

Indexed as

CD4CD8gastric carcinomainfiltrating T cellProgrammed death-1 ligand-1

Identifiers

PMID31966537
PMCPMC6966033
OpenAlexW3027215283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.