ArticleInternational journal of clinical and experimental pathology2017
Platelet-rich plasma promotes cell viability of human hair dermal papilla cells (HHDPCs) in vitro.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Regeneration Through Platelet Rich Plasma - A Cell Therapy with a Path Full of Milestones, Controversies and Cautions!Indian dermatology online journal · 2021Article
- Platelet-Rich Plasma in Androgenetic Alopecia.Indian dermatology online journal · 2021Article
- The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep.Veterinary world · 2018Article
- Expansion of Human Dermal Papilla Cells for Clinical Applications Using Human Platelet-rich Plasma as a Substitute for Fetal Bovine Serum.International journal of trichologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to clarify the effect of platelet-rich plasma (PRP) on human hair dermal papilla cell (HHDPC) viability and expression levels of alkaline phosphatase (ALP) and versican.
methodsEight healthy volunteers were enrolled, and different concentrations of PRP and platelet-poor plasma (PPP) were preparedby 2-step centrifugation method. HHDPCs were thencultivated. To identify the best incubating time of HHDPCs and plasmaconcentration, cell viability was investigated by MTT assays. In PRP- or PPP-treated HHDPCs, the mRNA levels of versican and ALP were checked by real-time quantitative PCR (qRT-PCR).
resultsBoth PRP (5% and 10%) and PPP (5% and 10%) could significantly promote cell viability of the HHDPCs (p4) in 72 h group, while the effect of 10% PRP on HHDPC viability was less than that of 5% PRP. qRT-PCR showed that PRP could significantly increase mRNA levels of ALP and versican in HHDPCs (p4) when compared with the control group. Meanwhile,Western blot indicated an obviously increased protein level of ALP and versican in PRP-treated HHDPCs (p4).
conclusionPRP could promote cell viability of HHDPCs. Besides, 5% PRP could significantly increase ALP and versican expression in both mRNA and protein levels in HHDPCs (p4).
Indexed as
Identifiers
31966530PMC6966016W3013254030What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.