Dynamaic changes of proliferation and apoptosis in rat retina development.

Weibo Shi, Ran Wang, Shiba Niu, Yingmin Li, Chunling Ma, Guozhong Zhang, Bin Cong

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Self-Organization of the Retina during Eye Development, Retinal Regeneration In Vivo, and in Retinal 3D Organoids In Vitro.Biomedicines · 2022
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Weibo ShiDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Ran WangDepartment of Psychiatry, The First Hospital of Hebei Medical University Shijiazhuang, China.

Shiba NiuDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Yingmin LiDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Chunling MaDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Guozhong ZhangDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Bin CongDepartment of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification Shijiazhuang, China.

Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise coordination of cell proliferation and apoptosis is essential for proper organ morphogenesis and function during mammalian development. The retina is a part of the central nervous system, with a function in capture and conversion of light particles into nerve signals. However, the dynamical changes of cell proliferation and apoptosis during the retinal development is unclear. Thus, this study was to observe the changes of proliferating cell nuclear antigen expression and apoptosis during the retina development in rats. Rats from different developmental stages (embryonic days 14-20 (E14-20), postnatal days 0-15 (P0-15) and adult (P36)) were used. The eyeballs were removed and fixed immediately in formalin. The tissues were embedded in paraffin. Sections were prepared for immunohistochemical staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL). PCNA expression appeared in large quantities in rat retina from E14 to P7, decreased obviously since P9, and could not be observed since P15. Apoptotic cells appeared in small quantities since E18. And then apoptotic cells dramatically increased during the retina development, and peaked at P7. As maturation continued, these cells decreased gradually. Apoptotic cells could not be found in the mature retina. Cell proliferation and apoptosis shows orderly and dynamic changes during the retina development, which is essential for the development of normal structure and function of the retina.

Indexed as

apoptosisdevelopmentproliferating cell nuclear antigenproliferationRetina

Identifiers

PMID31966527

PMCPMC6966058

OpenAlexW3027327168

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.