ArticleInternational journal of clinical and experimental pathology2017
Serum miR-133b is a potential novel prognostic biomarker for colorectal cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Downregulation of Serum miR-133b and miR-206 Associate with Clinical Outcomes of Progression as Monitoring Biomarkers for Metastasis Colorectal Cancer Patients.MicroRNA (Shariqah, United Arab Emirates) · 2024Article
- Liquid Biopsy as a Source of Nucleic Acid Biomarkers in the Diagnosis and Management of Lynch Syndrome.International journal of molecular sciences · 2022Review
- Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression.Aging · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeregulation of microRNA-133b (miR-133b) has been demonstrated to contribute to the initiation and development of various cancers including colorectal cancer (CRC). However, the correlation between serum miR-133b levels and the prognosis of CRC remains elusive.
methodsA total of 98 CRC patients, 30 patients with precancerous polyps and 40 healthy volunteers were enrolled in this study. Quantitative real-time PCR (qRT-PCR) was performed to measure the serum miR-133b expression level in all the participants. The chi-square test was carried out to compare the categorical variables. Furthermore, survival analysis and cproportional hazards
resultsSerum miR-133b level was progressively down-regulated from healthy controls, patients with precancerous polyps to CRC patients. CRC patients with higher clinical stage or lymph node metastasis had lower serum miR-133b levels. A positive correlation was found between decreased serum miR-133b levels and distant metastasis, lymph node metastasis and clinical stage. Additionally, CRC patients with high serum miR-203 levels had better 5 year overall survival and relapse free survival rates. Finally, low serum miR-133b level was demonstrated to be an independent risk factor for CRC.
conclusionThese findings suggest that miR-133b might serve as a novel potential prognostic biomarker for CRC.
Indexed as
Identifiers
31966526PMC6966027W3027210562What OpenQuestion holds
Registered trials
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