ArticleInternational journal of clinical and experimental pathology2017
Serum CEA level lost its prognostic value in gastric cancer patients with AB blood type.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLittle is known about the relationship between ABO blood groups and serum CEA level in gastric cancer patients. The aim of this study was to investigate the prognostic value of serum CEA level in gastric cancer patients with different ABO blood types. MATERIALS AND
methodsFrom September 2008 to April 2015, a total of 3234 gastric cancer patients who underwent radical gastrectomy were retrospectively analyzed in our institution. The clinicopathological characteristics and survivals were recorded. The prognostic value of serum CEA level within different ABO blood groups were analyzed.
resultsThe ratio of male to female patients was 3.5:1. The median age was 57.4 years (range 20-87). In all, 980 cases (30.3%) were blood type A, 935 cases (28.9%) were blood type B, 331 cases (10.2%) were blood type AB and 988 cases (30.6%) were blood type O. The positive rate of preoperative serum CEA was 19.0%. The overall survival of patients with negative and positive CEA level were 60.2% vs 34.4% for A blood type (P<0.001), 63.6% vs 44.5% for B blood type (P<0.001), 64.7% vs 36.2% for O blood type (P<0.001), 59.9% vs 46.1% for AB blood type (P=0.210). Serum CEA level was an independent prognostic factor for patients with A, B, O blood type (all P<0.05). However, serum CEA level was not a prognostic factor for patients with AB blood type (P=0.898). The level of CEA were significantly associated with gender, tumor size, tumor location, differentiation degree, tumor depth and lymph node metastasis in patients with AB blood type (all P<0.05).
conclusionsSerum CEA was an independent prognostic factor in gastric cancer patients with non-AB blood type, but lost its prognostic value in patients with AB blood type.
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31966522PMC6966059What OpenQuestion holds
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