ArticleInternational journal of clinical and experimental pathology2017
Dact3 inhibits the malignant phenotype of non-small cell lung cancer through downregulation of c-Myb.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Role of MicroRNA-214 in Dishevelled1-Modulated β-catenin Signalling in Non-Small Cell Lung Cancer Progression.Journal of Cancer · 2023Article
- CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy.Biomolecules & therapeutics · 2022Article
- Targeting miR-9 in Glioma Stem Cell-Derived Extracellular Vesicles: A Novel Diagnostic and Therapeutic Biomarker.Translational oncology · 2022Article
- Transcription factor c-Myb: novel prognostic factor in osteosarcoma.Clinical & experimental metastasis · 2022Article
- The Role of DACT Family Members in Tumorigenesis and Tumor Progression.International journal of biological sciences · 2022Review
- Identification of Lymph Node Metastasis-Related Key Genes and Prognostic Risk Model in Bladder Cancer by Co-Expression Analysis.Frontiers in molecular biosciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dact3 is a negative regulator of Wnt/β-catenin signaling. c-Myb promotes tumor cell invasion through Wnt/β-catenin pathway. However, the detailed mechanism by which Dact3 and c-Myb modulate the progression of non-small cell lung cancer (NSCLC) remains unclear. In this study, the expressions of Dact3 and c-Myb in 254 surgically resected NSCLC samples were detected by immunohistochemistry. We transfected Dact3 cDNA to A549 and H157 cells or siRNA-Dact3 to SPC cells and examined above effects on the activity of Wnt/β-catenin signaling by Western blot and luciferase activity assay, in addition to cell biological behavior by Transwell and MTT assay. Dact3 expression was reduced in NSCLC tissue. Reduced Dact3 expression was correlated with lymph node metastasis and poor prognosis of NSCLC (P<0.05). In addition, Dact3 expression was negatively correlated with the c-Myb expression (R = -0.626, P<0.05). Dact3 transfection resulted in c-Myb reduced expression in NSCLC cells, as well as decreased activity of Wnt/β-catenin signaling and reduced cell invasive and proliferative capacity. siRNA-Dact3 transfection had the opposite effect. Our results indicate that Dact3 may inhibit the malignant phenotype of NSCLC through downregulation of c-Myb.
Indexed as
Identifiers
31966514PMC6966047W3010981228What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.