ArticleInternational journal of clinical and experimental pathology2017
Abnormal β-catenin expression and reduced tumor-infiltrating T cells are related to poor progression in non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- The role of microRNAs in modulating Wnt signaling pathway dynamics and their therapeutic implications in non-small cell lung cancer.Discover oncology · 2026Review
- Tumor β-catenin expression is associated with immune evasion in non-small cell lung cancer with high tumor mutation burden.Oncology letters · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was to identify the relationship between the expression of β-catenin and CD8+ T cells infiltration in non-small cell lung cancer (NSCLC).
methodsA total of 100 NSCLC patients undergoing lobectomy and lymph node dissection were enrolled in this study. The baseline demographics, histopathologic data, recurrence-free survival (RFS) period, and pathologic specimens preserved in paraffin were available for them. Immunohistochemistry (IHC) was carried out with resected, paraffin-embedded NSCLC tissues. Evaluation of tumor-infiltrating CD8+ T cells immunostaining was performed using a four-tiered scale according to the visual estimation on lymphocytes.
resultsA significant association was found between reduced β-catenin expression and nodal involvement (
conclusionAbnormal β-catenin expression might suppress antitumor activity by decreasing tumor-infiltrating CD8+ T cells. Inhibition of β-catenin expression and/or activity might be used as a component of anti-cancer immunotherapy in the future.
Indexed as
Identifiers
31966513PMC6966022W3028109006What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.