ArticleInternational journal of clinical and experimental pathology2017
Brahma compensates the role of brahma-related gene 1 in liver regeneration of
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Acute depletion of BRG1 reveals its primary function as an activator of transcription.Nature communications · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundBrahma-related gene 1 and brahma, which are catalytic components of the mammalian chromatin remodeling complex, express ubiquitously in mammalian tissues, including the liver. Although both are involved in numerous biological processes, including cell growth, proliferation, and tumorigenesis, their roles in liver regeneration are still unclear.
methodsWe developed special knockout mice in which brahma-related gene 1 was deleted in the hepatocytes. After that, partial hepatectomy and chemical injury models were used to investigate the regulation process in liver regeneration.
resultsNotably, brahma-related gene 1 increased in liver regeneration following hepatic injury; however, the loss of brahma-related gene 1 neither prominently disturbed the development, growth, and metabolism of the liver nor impaired liver regeneration even after inducing tumorigenesis. In contrast, the brahma expression maintained at stable levels in the early phase of liver regeneration. Intriguingly, additional brahma silencing in
conclusionsIn contrast to the accepted notion that brahma could compensate the role of brahma-related gene 1 in liver regeneration by increasing its expression volume, the results of this study found that the deficiency of both brahma-related gene 1 and brahma significantly delays liver regeneration.
Indexed as
Identifiers
31966512PMC6966071What OpenQuestion holds
Registered trials
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