ArticleInternational journal of clinical and experimental pathology2017
Accumulated autophagosomes and excessive apoptosis during the luteal development of pregnant rats.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- A matter of new life and cell death: programmed cell death in the mammalian ovary.Journal of biomedical science · 2024Review
- Interplay between nitric oxide and gonadotrophin-releasing hormone in the neuromodulation of the corpus luteum during late pregnancy in the rat.Reproductive biology and endocrinology : RB&E · 2022Article
- Neuromodulatory effect of GnRH from coeliac ganglion on luteal regression in the late pregnant rat.Cell and tissue research · 2021Article
- HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy.Frontiers in cell and developmental biology · 2021Article
- HIF-1α/BNIP3-Mediated Autophagy Contributes to the Luteinization of Granulosa Cells During the Formation of Corpus Luteum.Frontiers in cell and developmental biology · 2020Article
- Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.Cells · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy plays an important role in the regression of pseudopregnant corpus luteum, whereas the involvement of autophagy in the pregnant luteolysis still remains unknown. Therefore, the present study was designed to investigate the levels and effects of accumulated autophagosomes on excessive apoptosis during the luteal development of pregnant rats. Ovaries were obtained from the female rats at the early, middle or late phase of the pregnancy, which correspondingly had three groups; including the early (ELP), middle (MLP) and late luteal phase (LLP). The results of autophagy-associated protein LC-3 clearly showed that autophagy expressed during the pregnant CL and significantly increased at LLP, while the expression changes of apoptosis related proteins cleaved caspase-3 and Bax were similar with LC-3 expression changes, indicating autophagy may be involved in the initiation of pregnant luteolysis through the induction of cellular apoptosis at LLP of pregnant ovaries. The present study was further examined the expressions of other two autophagy-associated proteins p62 and LAMP-2, since the degradation failure of autophagosomes contributed to cellular apoptosis. The results demonstrated p62 protein was accumulated at LLP while its mRNA was maintained during the whole luteal development of pregnant rats. Interestingly, the expressions of LAMP-2 mRNA and premature protein were significantly increased at MLP and LLP, while the expression of mature LAMP-2 increased at MLP and then decreased at LLP, implying autophagosomes were accumulated at LLP. Together, to our knowledge, the present study firstly demonstrated that the insufficient of lysosomal functions contributed to the impaired degradation of autophagosomes and then activated caspase-3 dependent apoptotic pathway during the pregnant luteolysis of rat ovaries, which will provide a new insight into the important mechanism regulating the luteolysis of the pregnant ovaries in mammals.
Indexed as
Identifiers
31966494PMC6966024W3014175018What OpenQuestion holds
Registered trials
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