ArticleInternational journal of clinical and experimental pathology2017
Hemolytic streptococcus exacerbates tubulointerstitial lesions in IgA nephropathy through Th22 cells chemotaxis and proliferation.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- CCR10: a comprehensive review of its function, phylogeny, role in immune cell trafficking and disease pathogenesis.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTonsillitis and the immunopathologic response induced by it are essential for IgA nephropathy (IgAN) progression. In this study, we investigated the possible mechanism underlying Th22 cells overrepresentation in tonsillitis related IgAN.
methodsThe distribution of Th22 cells, and the expressions of CCR10 and CCL27 in IgAN patients were detected. Relationship between Th22 cell chemotaxis and renal pathology lesions was determined. Transwell assay was performed to investigate the contribution of human tubular epithelial cell (human kidney 2 cell, HK2) to Th22 cell chemokines underlying Hemolytic streptococcus (HS) infection. Additionally, the impacts of tubular inflammatory on Th22 cell proliferation were investigated.
resultsTh22 cells were significantly increased in IgAN patients. Accordingly, the expressions of CCR10 and CCL27 were increased in IgAN patients. Higher Th22 cells, CCR10 and CCL27 correlated with severer tubulointerstitial lesions. It was observed that CCR10 and CCL27 were predominantly expressed on tubular epithelial cells, and supernatants of HK2 were chemotactic for Th22 cells. This activity of HK2 was partly blocked by anti-CCL27. Tonsillitis promoted the over expression of Th22 cells, CCR10 and CCL27 in IgAN patients, and exacerbated their renal lesions. Inactivated HS aggravated Th22 cell chemotaxis by promoting CCL27 secretion. Additionally, inactivated HS could accelerate Th22 cell proliferation by promoting the secretion of IL-1, IL-6 and TNF-α.
conclusionTh22 cell chemotaxis was involved in the pathogenesis of IgAN. Tubular epithelial cells are vulnerable to Th22 cell chemotaxis in IgAN. Tonsillitis may exacerbate the progression of IgAN by promoting Th22 cell chemotaxis and cell proliferation.
Indexed as
Identifiers
31966477PMC6965818W3028552469What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.