ArticleInternational journal of clinical and experimental pathology2017
Anaplastic lymphoma kinase-positive large B-cell lymphoma with a diagnostic pitfall of carcinoma: a case report.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 3 institutions in 1 country.
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Abstract
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+LBCL) is a rare non-Hodgkin lymphoma that exhibits a characteristic immunoblastic/plasmablastic morphology and is frequently expressing Clathrin-anaplastic lymphoma kinase fusion protein. Since being negative for T- and B- linage markers, this tumor is easy to be misdiagnosed, especially when it has unusual morphology and immunophenotype. Here, we report an ALK+LBCL with a diagnostic pitfall of carcinoma. The patient was a 28-year-old man with enlargement of a right submandibular lymph node. Morphologically, the lymph node had an unusual nodular growth pattern, with nodules surrounded by collagen bands. The neoplastic cells expressed epithelial membrane antigen, CD138, CD38, Mum-1, but negative for T- and B- linage markers, and showed a strong granular cytoplasmic Anaplastic Lymphoma Kinase staining pattern. Some tumor cells had the expressing of Cytokeratin.
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31966473PMC6965820W3027028610What OpenQuestion holds
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