Evidence map›Paper›PMID 31966453›Full record

ArticleInternational journal of clinical and experimental pathology2017

Dynamic changes in trauma-induced myeloid-derived suppressor cells after polytrauma are associated with an increased susceptibility to infection.

Liang Cheng, Jia Xu, Yimin Chai, Chunyang Wang, Pei Han

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liang ChengDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Jia XuDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Yimin ChaiDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Chunyang WangDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Pei HanDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China.
Shanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a strong association between severity of injury and an increased susceptibility to infection after injury. T cell dysfunctions are central to the development of infections following a trauma. Trauma-induced myeloid-derived suppressor cells (MDSCs) can suppress T cell functions, and the process is associated with poor clinical outcome. In this study, we compared the dynamic changes in trauma-induced MDSCs in two trauma animal models.

methodsRats were divided into three groups as follows: the control group, the femur fracture (FFx) group, and the polytrauma (PT) group. Animals were sacrificed at 2, 6, 12, 18, or 24 h postoperatively, and spleen was harvested for study. The MDSCs were identified by a flow cytometry and calculated. Incorporation of [

conclusionThese results suggest that polytrauma stress represent a more extensive MDSCs expansion which may contribute to an increased susceptibility to infection.

Indexed as

injury severitymyeloid-derived suppressor cellsPolytrauma

Identifiers

PMID31966453
PMCPMC6965885
OpenAlexW3026976681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.