ArticleInternational journal of clinical and experimental pathology2017
Inflammatory cytokine profiles of serum and cerebrospinal fluid in Chinese children with hand, foot and mouth disease.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Pooled it
- Correlation analysis of serum inflammatory cytokine levels and immune markers in children with severe hand, foot and mouth disease.The Journal of international medical research · 2024Article
- Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm.Frontiers in immunology · 2024Article
- IP-10 acts early in CV-A16 infection to induce BBB destruction and promote virus entry into the CNS by increasing TNF-α expression.Frontiers in immunology · 2024Article
- Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHand, foot and mouth disease (HFMD) is mainly caused by enterovirus 71 (EV71) or coxsackie virus A16 infection. Severe HFMD with encephalitis is a life-threatening disease for children. This study aimed to examine the levels of a variety of inflammatory cytokines in HFMD patients.
methodsSera of severe or common HFMD patients and cerebrospinal fluids from severe HFMD patients in the acute or recovery phase were collected to analyse 40 cytokines using the Raybiotec Cytokine array. Twenty-six samples of sera or cerebrospinal fluids from HFMD patients were further detected using Milliplex beads.
resultsNumerous inflammatory cytokines, such as IL-8, IP-10, and RAENTES, were enhanced in the sera and cerebrospinal fluids of encephalitis-complicated HFMD patients. Serum IL-12p40 and IL-15 levels were higher in severe HFMD patients compared with common patients. Moreover, IL-8 and IP-10 levels in the cerebrospinal fluid were sharply enhanced by 30-fold on average compared with those in the sera. Cerebrospinal fluid IL-8, IP-10, and RANTES levels were significantly enhanced in the acute phase of severe HFMD patients compared with those in the recovery phase. However, no correlation of serum IL-8 or IP-10 level with its cerebrospinal fluid level was observed.
conclusionAn inflammatory cytokine storm occurs both in sera and cerebrospinal fluids during severe HFMD, which is likely a Th1 cell-associated disease. Cerebrospinal fluid IL-8, IP-10 and RANTES levels could be used as potential biomarkers for diagnosing severe HFMD, whereas the enhanced serum levels of IL-12p40 and IL-15 could be used as candidate predictive factors for severe HFMD.
Indexed as
Identifiers
31966447PMC6965817W3026131692What OpenQuestion holds
Registered trials
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