ArticleInternational journal of clinical and experimental pathology2017
USP43 promotes tumorigenesis through regulating cell cycle and EMT in breast cancer.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular regulation by ubiquitin-specific proteases (USPs) in HCC: cell cycle, oncogenic signaling, and beyond.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- USP43 promotes cerebral ischemia-reperfusion injury via activation of TAK1.Cell & bioscience · 2025Article
- The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation.Cell death and differentiation · 2025Article
- Ethoxychelerythrine as a potential therapeutic strategy targets PI3K/AKT/mTOR induced mitochondrial apoptosis in the treatment of colorectal cancer.Scientific reports · 2025Article
- Review
- USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/β-catenin signaling pathway.Apoptosis : an international journal on programmed cell death · 2024Article
- Ubiquitin-Specific Protease 43 Impacts Pancreatic Ductal Adenocarcinoma Prognosis by Altering Its Proliferation and Infiltration of Surrounding Immune Cells.Journal of immunology research · 2023Article
- Article
- USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer.Journal of Cancer · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
USP is one protease family of deubiquitylating enzyme (DUB). It removes ubiquitin from substrate and stabilizes the substrate. Here, we scanned several novel deubiquitinate enzymes in breast cancer tissue samples, and found that USP43 was up-regulated in breast cancer and closely relationship with metastasis, tumor size and a poor prognosis. Consequently, CCK-8 assay and colony formation assay were used to assess the function of USP43 in cell proliferation. Moreover, cell apoptosis assay and cell cycle assay revealed that USP43 facilitated cells G
Indexed as
Identifiers
31966446PMC6965873W3006149220What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.