ArticleInternational journal of clinical and experimental pathology2017
Early maternal separation promotes apoptosis in dentate gyrus and alters neurological behaviors in adolescent rats.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Long-Term Impact of Early-Life Stress on Hippocampal Apoptotic Gene Expression in BALB/c Mice.Neurochemical research · 2026Article
- Nutritional interventions to counteract the detrimental consequences of early-life stress.Molecular psychiatry · 2025Review
- Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress.Schizophrenia (Heidelberg, Germany) · 2023Article
- Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders.Biomolecules · 2023Article
- A Novel Early Life Stress Model Affects Brain Development and Behavior in Mice.International journal of molecular sciences · 2023Article
- Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes.Biological research · 2021Article
- Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF.Acta pharmacologica Sinica · 2019Article
- Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse early-life experience such as maternal separation (MS) affects the behavior of adult, and may also aggravate the outcome of neurological insults. In this study, we aimed to investigate the effects of early MS on hippocampus-related behaviors, and to assess the mechanisms. Newborn rats were randomly divided into normal control and MS groups. Our data showed that MS (P3-P21) impaired learning ability as well as memory retrieval, and caused depression-like activity, but decreased anxiety-like activity. Glutamate receptor 1 (GluR1) expression in the dentate gyrus (DG) region was significantly reduced in the adults (P60). Mechanically, MS promoted apoptosis, and reduced protein kinase B (AKT) phosphorylation in the DG region in the early phase (P21). By contrast, MS did not affect ERK phosphorylation. Our data implicate that the inactivation of AKT pathway and apoptosis of DG cells might contribute to MS-induced behavioral changes. This study would provide useful evidence implicating the pathological changes for MS.
Indexed as
Identifiers
31966424PMC6965815W3026964941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.