ArticleInternational journal of clinical and experimental pathology2017
CUL4A enhances human trophoblast migration and is associated with pre-eclampsia.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- MicroRNAs: key regulators of the trophoblast function in pregnancy disorders.Journal of assisted reproduction and genetics · 2023Review
- Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes.American journal of human genetics · 2022Article
- Ubiquitin ligases: guardians of mammalian development.Nature reviews. Molecular cell biology · 2022Review
- Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells.Bioengineered · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously found that cullin 4A (CUL4A) is able to promote trophoblast invasion. However, the role of CUL4A in other trophoblast behavior such as migration and the association with pregnancy disorder remains unclear. In this study, Immunostaining revealed that CUL4A was relatively lowly expressed in placentas from pre-eclampsia patients compared with the normal controls. Spiral arteries and inadequate trophoblast migration remodeling result in poor placental perfusion, which mediated maternal injury and may lead to pre-eclampsia. To confirm CUL4A's function on trophoblast migration, we employed human villous explants culture and trophoblast cell line HTR-8/SVneo migration and invasion assay. According to our data, knocking-down CUL4A expression inhibited villous explant's outgrowth significantly
Indexed as
Identifiers
31966394PMC6965756W3014203351What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.