ArticleInternational journal of clinical and experimental pathology2017
Meprin α combined with CEA and CA19-9 improves prognostic prediction for surgically treated colorectal cancer patients.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are generally used as tumour markers in patients with colorectal cancer (CRC), and meprin α might be an additional marker.
methodsThe preoperative expression of serum CEA and CA19-9 was evaluated using a C12 protein biochip system, and tissue meprin α expression in CRC cells was detected by immunohistochemistry. The relationships of these indexes with clinicopathological parameters and the survival of CRC patients were analysed.
resultsOf the 147 CRC patients, the preoperative seropositive rates for CEA and CA19-9 were 51.70% and 44.22%, respectively, and the tissue meprin α positive rate was 39.46%. Preoperative seropositivity for CEA was correlated with tumour size (
conclusionsTissue meprin α expression may be a useful predictor of metastasis and prognosis in CRC. The combined detection of the three markers may also be helpful to improve the accuracy of CRC prognosis monitoring.
Indexed as
Identifiers
31966381PMC6965749W3027478060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.