ArticleInternational journal of clinical and experimental pathology2017
Exogenous WWOX enhances apoptosis and weakens metastasis in CNE2 nasopharyngeal carcinoma cells through the intrinsic apoptotic pathway.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Novel Hydrogel-Mediated Lentiviral Gene Delivery via Intravesical Administration for Bladder Cancer Treatment.Pharmaceutics · 2025Article
- MicroRNA-21 depletion by CRISPR/Cas9 in CNE2 nasopharyngeal cells hinders proliferation and induces apoptosis by targeting the PI3K/AKT/MOTOR signaling pathway.International journal of clinical and experimental pathology · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
The WW domain containing oxidoreductase (WWOX) has been postulated to behave as a putative tumor suppressor and that silencing of WWOX expression is linked to the carcinogenesis and progression of various carcinomas. The role of WWOX in nasopharyngeal carcinoma (NPC) remains unclear. Herein, we sought to evaluate the biological feature of WWOX restoration in human CNE2 NPC cells. In vitro experiments manifested that transiently overexpressed WWOX significantly suppressed proliferation as well as invasion and migration of the CNE2 cells. Of note, WWOX-induced apoptosis could be partly reversed by the selective caspase inhibitor, Z-VAD-FMK. Furthermore, immunoblotting analysis indicated that ectopic expression of WWOX could trigger the intrinsic apoptotic signaling pathway characterized by a down-regulation of Bcl-2 and Bcl-xL, and up-regulation of Bax and Cytochrome c along with a remarkable activation of the caspase cascades. Taken together, our data reveal that WWOX behaves as a potent tumor suppressor in CNE2 cells, possibly by enhancing apoptosis and weakening metastasis via the intrinsic apoptotic pathway.
Indexed as
Identifiers
31966369PMC6965803W3028204405What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.