ArticleInternational journal of clinical and experimental pathology2017
MiR-7684-5p leads to surgery-induced cognitive decline in mice probably through the downregulation of SorLA.
Article in International journal of clinical and experimental pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
backgroundPostoperative cognitive dysfunction is a postoperative severe complication caused by many factors. However, its specific pathogenesis remains unclear. MicroRNAs (miRNAs), which are involved in the pathogenesis of neurodegenerative diseases, may also affect POCD.
methodsIn this research, microarray technology was used to screen 26 miRNAs that had a differential expression in the hippocampus of mouse between the surgery group and control group. The qRT-PCR verification on the hippocampuses of 10 pairs of mouse testifies the high expression of miR-7684-5p in the surgery group (identical with the result of chip).
resultsSurgical trauma was found to induce the expression of miR-7684-5p with the accumulation of Aβ in the hippocampus. Furthermore, miR-7684-5p knockdown effectively reduced the levels of Aβ triggered by surgery, and attenuated hippocampal-dependent memory impairment. Moreover, we testify that sorLA is a target gene of miR-7684-5p through bioinformatics prediction and dual-luciferase report gene experiment.
conclusionsOur data indicate that decreased postoperative cognitive function may be caused by the increased generation of Aβ by reducing sorLA expression. Our work implicates miR-7684-5p as a potential biomarker and a novel therapeutic target.
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31966352PMC6965804What OpenQuestion holds
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