ArticleBiomicrofluidics2020
A droplet-based microfluidic viscometer for the measurement of blood coagulation.
Article in Biomicrofluidics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- [Research on blood viscoelasticity detection based on electrowetting technology].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Microfluidic Chip for Quantitatively Assessing Hemorheological Parameters.Micromachines · 2025Article
- A New Shear-Stress-Based Point-of-Care Technology for Evaluation of the Hemostatic Pattern in Whole Blood.Biosensors · 2024Article
- Quantification of Blood Viscoelasticity under Microcapillary Blood Flow.Micromachines · 2023Article
- Microfluidic techniques for mechanical measurements of biological samples.Biophysics reviews · 2023Review
- Biomechanical Assessment of Red Blood Cells in Pulsatile Blood Flows.Micromachines · 2023Article
- Strain Sensor-Inserted Microchannel for Gas Viscosity Measurement.Biosensors · 2023Article
- Single Microdroplet Breakup-Assisted Viscosity Measurement.Micromachines · 2022Article
- A Review of Microfluidic Devices for Rheological Characterisation.Micromachines · 2022Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A continuous microfluidic viscometer is used to measure blood coagulation. The viscometer operates by flowing oil and blood into a cross section where droplets are generated. At a set pressure, the length of the droplets is inversely proportional to the viscosity of the blood sample being delivered. Because blood viscosity increases during coagulation as the blood changes from a liquid to a solid gel, the device allows to monitor coagulation by simply measuring the drop length. Experiments with swine blood were carried out in its native state and with the addition of coagulation activators and inhibitors. The microfluidic viscometer detected an earlier initiation of the coagulation process with the activator and a later initiation with the inhibitor compared to their corresponding controls. The results from the viscometer were also compared with the clinical method of thromboelastography (TEG), which was performed concurrently for the same samples. The time to initiation of coagulation in the microfluidic viscometer was correlated with the reaction time in TEG. Additionally, the total time for the measurement of clot strengthening in TEG correlated with the time for the maximum viscosity observed in the microfluidic viscometer. The microfluidic viscometer measured changes in viscosity due to coagulation faster than TEG detected the clot formation. The present viscometer is a simple technology that can be used to further study the entire coagulation process.
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Registered trials
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