Evidence map›Paper›PMID 31966071›Full record

ArticleOncology letters2020

MicroRNA-519 inhibits hypoxia-induced tumorigenesis of pancreatic cancer by regulating immune checkpoint PD-L1.

Kate Nong, Dong Zhang, Changze Chen, Yue Yang, Yong Yang, Shengyong Liu, Huihua Cai

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kate NongDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Dong ZhangDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Changze ChenDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Yue YangDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Yong YangDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Shengyong LiuDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Huihua CaiDepartment of Surgery of The Liver, Biliary Tract, and Pancreas, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is highly prevalent and exhibits a high incidence and mortality rate. Hypoxia contributes to tumorigenesis and the progression of pancreatic cancer. To the best of our knowledge, the role of microRNA (miR)-519 has not been investigated in hypoxia-induced pancreatic cancer progression. The purpose of the present study was to elucidate the mechanism underlying miR-519-mediated regulation of pancreatic cancer progression. Reverse transcription-quantitative PCR and western blotting were performed to investigate miR-519 and programmed death ligand 1 (PD-L1) mRNA and protein levels, respectively. Additionally, a Transwell assay was performed to examine the invasiveness of PANC-1 and SW1990 cells. Cells were subsequently stained with Annexin V to determine the apoptotic rate of cells. Furthermore, bioinformatics analysis and a dual-luciferase reporter assay were performed to confirm the direct association between miR-519 and PD-L1, and a xenograft experiment was conducted to test the role of miR-519

Indexed as

hypoxiamicroRNA-519pancreatic cancerprogrammed death ligand 1tumorigenesis

Identifiers

PMID31966071
PMCPMC6956369
OpenAlexW2995652414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.