ReviewParasitology2020
Schistosomiasis then and now: what has changed in the last 100 years?
Review in Parasitology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Metalloids: Semi as Metals yet Full of Antimicrobial Potential.ChemMedChem · 2026Review
- Shared urinary metabolomic signatures as potential biomarkers for early intestinalCurrent research in parasitology & vector-borne diseases · 2026Article
- Prevalence and factors associated with urinary schistosomiasis in women attending cervical cancer screening in Sithobela, Eswatini: A facility-based cross-sectional study.Helminthologia · 2025Article
- Pancreatic Schistosomiasis, China, 2020-2024.Emerging infectious diseases · 2025Article
- Praziquantel Pretreatment ReducesTropical medicine and infectious disease · 2025Article
- Analysis of DNA cox1 barcoding revealed novel haplotype in Schistosoma haematobium isolated from Western Sudan.Scientific reports · 2025Article
- Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and oviposition effects.Memorias do Instituto Oswaldo Cruz · 2025Article
- Schistosomiasis Chemotherapy, Chemoprevention, and Vaccines: History, Progress, and Priorities.Immunity, inflammation and disease · 2024Review
- Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis.Frontiers of medicine · 2024Article
- Long Non-Coding RNA Levels Are Modulated inNon-coding RNA · 2024Article
- Schistosomiasis.Advances in experimental medicine and biology · 2024Review
- Modelling the age-prevalence relationship in schistosomiasis: A secondary data analysis of school-aged-children in Mangochi District, Lake Malawi.Parasite epidemiology and control · 2023Article
- Blocking BAFF Alleviates Hepatic Fibrosis inPathogens (Basel, Switzerland) · 2023Article
- Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility.PLoS pathogens · 2023Article
- Chemistry and Bioactivity ofMolecules (Basel, Switzerland) · 2023Article
- Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.Parasites & vectors · 2022Article
- Neuroretinitis with secondary retinal venous stasis in a patient with Schistosomiasis.American journal of ophthalmology case reports · 2022Article
- Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies.Acta crystallographica. Section D, Structural biology · 2022Article
- cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner.PLoS pathogens · 2022Article
- Untargeted serum metabolomic profiling for early detection ofFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only with the completion of the life cycles of Fasciola hepatica in 1883 and 30 years later those of Schistosoma japonicum (1913), Schistosoma haematobium and Schistosoma mansoni (1915) did research on schistosomiasis really get underway. One of the first papers by Cawston in 1918, describing attempts to establish the means of transmission of S. haematobium in Natal, South Africa, forms the historical perspective against which to judge where we are now. Molecular biology techniques have produced a much better definition of the complexity of the schistosome species and their snail hosts, but also revealed the extent of hybridization between human and animal schistosomes that may impact on parasite adaptability. While diagnostics have greatly improved, the ability to detect single worm pair infections routinely, still falls short of its goal. The introduction of praziquantel ~1982 has revolutionized the treatment of infected individuals and led directly to the mass drug administration programmes. In turn, the severe pathological consequences of high worm burdens have been minimized, and for S. haematobium infections the incidence of associated squamous cell carcinoma has been reduced. In comparison, the development of effective vaccines has yet to come to fruition. The elimination of schistosomiasis japonica from Japan shows what is possible, using multiple lines of approach, but the clear and present danger is that the whole edifice of schistosome control is balanced on the monotherapy of praziquantel, and the development of drug resistance could topple that.
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