Evidence map›Paper›PMID 31965637›Full record

ReviewJournal of leukocyte biology2020

Regulation of IgE by T follicular helper cells.

Uthaman Gowthaman, Jennifer S Chen, Stephanie C Eisenbarth

Open access · greenAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Circulating TFH2 Cell Expansion and GZMKJournal of asthma and allergy · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Progressively differentiated TNature immunology · 2025
    Article
  17. Article
  18. Control of Asthma and Allergy by Regulatory T Cells.International archives of allergy and immunology · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Uthaman GowthamanDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-5484-7851
Jennifer S ChenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Stephanie C EisenbarthDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-1244-208X
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Immune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1M
Regulation of adaptive immunity by the NOD-like receptor NLRP10R01AI108829 · NIAID · YALE UNIVERSITY · PI EISENBARTH, STEPHANIE CAROLINE · 2014 to 2018
$2.1M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI108829NIAID NIH HHS R01 AI136942
6 · The paper itself

Abstract

Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the cellular pathway to high-affinity IgE is typically through sequential switching of IgG B cells. Further, in contrast to the previously held paradigm that a subset of CD4

Indexed as

AnaphylaxisAnimalsCell DifferentiationCell PlasticityHumansHypersensitivityImmunoglobulin ET-Lymphocytes, Helper-InducerImmunoglobulin EAllergyAnaphylaxisIgETfh cellsTh2 cells

Identifiers

PMID31965637
PMCPMC8314067
OpenAlexW3000784673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.