ArticleCerebellum (London, England)2021
Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.
Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Computational and Neural Evidence for Altered Fast and Slow Learning from Losses in Problem Gambling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.PLoS computational biology · 2023Article
- Classics to Contemporary of Saccadic Dysmetria and Oscillations.Cerebellum (London, England) · 2023Article
- Uncovering Essential Tremor Genetics: The Promise of Long-Read Sequencing.Frontiers in neurology · 2022Review
- Predictive modeling of spread in adult-onset isolated dystonia: Key properties and effect of tremor inclusion.European journal of neurology · 2021Article
- Lessons learned from the syndrome of oculopalatal tremor.Journal of computational neuroscience · 2021Review
- Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome.Cerebellum (London, England) · 2021Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
We examined the role of the cerebellum in patients with tremor-dominant cervical dystonia by measuring the adaptive capacity of rapid reflexive eye movements (saccades). We chose the saccade adaptation paradigm because, unlike other motor learning paradigms, the real-time modification of saccades cannot "wait" for the sensory (visual) feedback. Instead, saccades rely primarily on the internal reafference modulated by the cerebellum. The saccade adaptation happens over fast and slow timescales. The fast timescale has poor retention of learned response, while the slow timescale has strong retention. Cerebellar defects resulting in loss of function affect the fast timescale but the slow timescale of saccade adaptation is retained. In contrast, maladaptive cerebellar disorders feature the absence of both fast and slow timescales. We were able to measure both timescales using noninvasive oculography in 6 normal individuals. In contrast, both timescales were absent in 12 patients with tremor-dominant cervical dystonia. These findings are consistent with maladaptive cerebellar outflow as a putative pathophysiological basis for tremor-dominant cervical dystonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.