ArticleJournal of materials science. Materials in medicine2020
In vivo osseointegration of a randomized trabecular titanium structure obtained by an additive manufacturing technique.
Article in Journal of materials science. Materials in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06287021 (Bone Remodeling Around a 3D-printed Highly-porous Trabecular Titanium Acetabular Cup in Primary Total Hip Arthroplasty), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bone Remodeling Around a 3D-printed Highly-porous Trabecular Titanium Acetabular Cup in Primary Total Hip Arthroplasty
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- 3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Additively Manufactured Patient-Specific Trabecular Bone Imitations in Anatomical Bone Models for Preoperative Planning and Surgical Training: A Manufacturing Framework.Annals of biomedical engineering · 2026Article
- Early osseointegration of two in-house 3D-printed porous titanium implant designs: anFrontiers in surgery · 2026Article
- In-house 3D printed porous implants: does strontium-coating enhance osseointegration? AnFrontiers in surgery · 2026Article
- Advances in Titanium-Based Biomaterial for Human Bone Scaffolds: Narrative Review on Design, Fabrication, Surface Engineering, Implantation, and Biological Evaluation.Materials (Basel, Switzerland) · 2025Review
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Novel Clinical Applications of 3D-Printed Highly Porous Titanium for Off-the-Shelf Cementless Joint Replacement Prostheses.Biomimetics (Basel, Switzerland) · 2025Article
- Safety and preliminary efficacy of an electrically stimulated implant for mandibular bone regeneration: a pilot study in a large animal model.Clinical oral investigations · 2025Article
- Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration.Current issues in molecular biology · 2025Review
- Impact of Surface Finishing on Ti6Al4V Voronoi Additively Manufactured Structures: Morphology, Dimensional Deviation, and Mechanical Behavior.Materials (Basel, Switzerland) · 2024Article
- Acute total hip arthroplasty with a highly-porous multi-holes cup in elderly patients after traumatic acetabular fracture: A case series and literature review.Trauma case reports · 2024Article
- Hip arthrodesis conversion to dual mobility total hip arthroplasty in a young adult using a custom-made highly-porous titanium monobloc cup: A case report.International journal of surgery case reports · 2024Article
- Trabecular titanium cups in acetabular revision arthroplasty: analysis of 10-year survivorship, restoration of center of rotation and osteointegration.Archives of orthopaedic and trauma surgery · 2022Article
- Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers.International journal of molecular sciences · 2022Review
- Understanding the Role of Surface Modification of Randomized Trabecular Titanium Structures in Bone Tissue Regeneration: An Experimental Study.Medicina (Kaunas, Lithuania) · 2022Article
- A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications.Bio-design and manufacturing · 2022Review
- Microarchitecture of titanium cylinders obtained by additive manufacturing does not influence osseointegration in the sheep.Regenerative biomaterials · 2021Article
- Osseointegration of retrieved 3D-printed, off-the-shelf acetabular implants.Bone & joint research · 2021Article
- Peptide-Enriched Silk Fibroin Sponge and Trabecular Titanium Composites to Enhance Bone Ingrowth of Prosthetic Implants in an Ovine Model of Bone Gaps.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The additive manufacturing techniques (AM) are able to realize three-dimensional trabecular structures that mimic the trabecular structure of the bone. An in vivo study in sheep was carried out with the aim of assessing the bone response and the trend of osteointegration of a randomized trabecular titanium structure produced by the AM technique. In 6 sheep were implanted 84 specimens with a trabecular titanium structure (4 implants in the femur distal epiphysis; 4 implants in the tibial plate; 6 implants in the tibial shaft). Sheep were sacrificed at 3 postoperative time-points: 6 weeks, 10 weeks, 14 weeks. Histomorphometric analysis was performed for the evaluation of Bone Implant Contact, and Bone Ingrowth. A standard push-out test was used to analyze the mechanical characteristics of the bone-implant interface. The histomorphometric data and biomechanical tests showed a fast osseointegration of the specimens both in the cancellous and in the cortical bone. The quantitative analysis of osseointegration data in cancellous bone showed the percentage of the surface of the implant in direct contact with the regenerated bone matrix significantly improved from 28% at 6 weeks to 54% at 14 weeks. An early osseointegration occurred in cortical bone showing that 75% of surface of implant was in direct contact with regenerated bone after 6 weeks; this value increased to 85% after 14 weeks. Mechanical tests revealed an early improvement of mean peak load of implants at 10 weeks (4486 N ± 528 N) compared to values at 6 weeks (2516 N ± 910 N) confirming the high rate of progression of osseointegration in the cortical bone. The non-mineralized matrix followed an increasing process of mineralization almost completely after 14 weeks. The results of this study have showed a rapid osseointegration and excellent biocompatibility for a randomized trabecular titanium structure that should be confirmed by clinical investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.