ArticleEuropean radiology2020
Quantitative CT detects progression in COPD patients with severe emphysema in a 3-month interval.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Management of Adult Bronchiectasis: Consensus-Based Guidelines of the German Respiratory Society.Respiration; international review of thoracic diseases · 2026Guideline
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- Quantitative and qualitative lung parameters in photon-counting CT: comparison of ultra-low-dose with standard low-dose protocols.European radiology · 2026Article
- CT image-based machine learning models for predicting blood eosinophil levels in acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Quantitative Analysis of Bronchiectasis in Alpha-1 Antitrypsin Deficiency.Canadian respiratory journal · 2026Article
- A Prognostic Nomogram Combining Radiologic Emphysema and Clinical Parameters in Small Cell Lung Cancer.Cancer management and research · 2026Article
- Case Report: Nebulized autologous platelet-rich plasma associated with quantitative CT and clinical changes in a patient with COPD and chronic hypersensitivity pneumonitis.Frontiers in medicine · 2026Article
- Quantitative spectral computed tomography detects different patterns of airway wall thickening and contrast enhancement in infective lung disease: a feasibility study.European radiology · 2025Article
- Quantitative analysis of chest computed tomography in alpha-1-antitrypsin deficiency.Respiratory research · 2025Article
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- GOLD grade-specific characterization of COPD in the COSYCONET multi-center trial: comparison of semiquantitative MRI and quantitative CT.European radiology · 2025Article
- Article
- Quantitative CT analysis of idiopathic pulmonary fibrosis and correlation with lung function study.BMC pulmonary medicine · 2024Article
- Artificial intelligence in COPD CT images: identification, staging, and quantitation.Respiratory research · 2024Review
- Prediction of disease severity in COPD: a deep learning approach for anomaly-based quantitative assessment of chest CT.European radiology · 2024Article
- COPD stage detection: leveraging the auto-metric graph neural network with inspiratory and expiratory chest CT images.Medical & biological engineering & computing · 2024Article
- A Multicenter Study of COPD and Cognitive Impairment: Unraveling the Interplay of Quantitative CT, Lung Function, HIF-1α, and Clinical Variables.International journal of chronic obstructive pulmonary disease · 2024Article
- Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013-2016.International journal of chronic obstructive pulmonary disease · 2024Article
- Article
- Development of machine learning model to predict pulmonary function with low-dose CT-derived parameter response mapping in a community-based chest screening cohort.Journal of applied clinical medical physics · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesChronic obstructive pulmonary disease (COPD) is characterized by variable contributions of emphysema and airway disease on computed tomography (CT), and still little is known on their temporal evolution. We hypothesized that quantitative CT (QCT) is able to detect short-time changes in a cohort of patients with very severe COPD.
methodsTwo paired in- and expiratory CT each from 70 patients with avg. GOLD stage of 3.6 (mean age = 66 ± 7.5, mean FEV1/FVC = 35.28 ± 7.75) were taken 3 months apart and analyzed by fully automatic software computing emphysema (emphysema index (EI), mean lung density (MLD)), air-trapping (ratio expiration to inspiration of mean lung attenuation (E/I MLA), relative volume change between - 856 HU and - 950 HU (RVC
resultsThe average of the emphysema parameters (EI, MLD) increased significantly by 1.5% (p < 0.001) for the whole lung, whereas air-trapping parameters (E/I MLA, RVC
conclusionQCT detects short-time progression of emphysema in severe COPD. The changes were partly different among lung lobes and airway generations, indicating that QCT is useful to address the heterogeneity of COPD progression. KEY POINTS: • QCT detects short-time progression of emphysema in severe COPD in a 3-month period. • QCT is able to quantify even slight parenchymal changes, which were not detected by spirometry. • QCT is able to address the heterogeneity of COPD, revealing inconsistent changes individual lung lobes and airway generations.
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