ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2020
Varus alignment of the proximal tibia is associated with structural progression in early to moderate varus osteoarthritis of the knee.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Defining and predicting radiographic knee osteoarthritis progression: a systematic review of findings from the osteoarthritis initiative.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Effects of a neuromuscular exercise program on lower limb alignment and balance ability in individuals with genu varum and knee pain.Journal of exercise rehabilitation · 2026Article
- Gait Biomechanics, Symmetry Restoration, and Functional Recovery Following Total Knee Arthroplasty: A Prospective Longitudinal Cohort Study.Life (Basel, Switzerland) · 2026Article
- Is multi-joint hip and knee osteoarthritis more than the sum of its parts?Osteoarthritis and cartilage open · 2026Article
- Altered gait strategies show inconsistent medial compartment unloading in varus medial knee osteoarthritis awaiting high tibial osteotomy.Clinical biomechanics (Bristol, Avon) · 2026Article
- Progression of bone and joint space deformity in patients with mild knee osteoarthritis: Data from the IMI-APPROACH cohort.Osteoarthritis and cartilage open · 2026Article
- Quantitative analysis of bony and soft tissue contributions to varus deformity across knee osteoarthritis stages.Journal of experimental orthopaedics · 2026Article
- Steeper medial posterior tibial slope is associated with medial meniscal extrusion and early-onset knee osteoarthritis in middle-aged Japanese women: A longitudinal cohort study.Journal of experimental orthopaedics · 2026Article
- Off-axis biomechanical alterations and related interventions in medial knee osteoarthritis: a mini review.Frontiers in rehabilitation sciences · 2026Review
- Medial Opening-Wedge High Tibial Osteotomy Delivers Meaningful Early Outcomes Even in KL-3 Osteoarthritis: A 24-Month Stratified Cohort Analysis.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Changes in spino-pelvis-lower extremity alignment in patients with knee osteoarthritis: a prospective radiographic study.Musculoskeletal surgery · 2025Article
- Body Mass Index and Spinopelvic Alignment as Predictors of Incident Knee Osteoarthritis: An 8-Year Longitudinal Study from the TOEI Cohort of Older Japanese Women.Journal of clinical medicine · 2025Article
- Stability characteristics of medial meniscus tear in mild varus knee: a finite element analysis.BMC musculoskeletal disorders · 2025Article
- HBP-A Attenuates Knee Osteoarthritis Progression via MLK3/P38/HDAC4 Axis-Mediated Dual Protection of Articular Cartilage and Quadriceps.Journal of cellular and molecular medicine · 2025Article
- Changes in the position of the medial meniscus owing to degenerative meniscus tears.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2025Article
- Do knee alignment patterns differ between Middle Eastern and East Asian populations? A propensity-matched analysis using artificial intelligence.Knee surgery & related research · 2025Article
- Medial meniscus root tears: mechanics, management, and techniques.Annals of joint · 2025Review
- Comparison of both lower leg bone mineral density in single limb knee osteoarthritis patients.Archives of orthopaedic and trauma surgery · 2023Article
- Automated Radiographic Measurements of Knee Osteoarthritis.Cartilage · 2023Article
- Greater medial proximal tibial slope is associated with bone marrow lesions in middle-aged women with early knee osteoarthritis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLower limb malalignment is a strong predictor of progression in knee osteoarthritis. The purpose of this study is to identify the individual alignment variables that predict progression in early to moderate osteoarthritis of the knee.
methodA longitudinal cohort study using data from the Osteoarthritis Initiative. In total, 955 individuals (1329 knees) with early to moderate osteoarthritis (Kellgren-Lawrence grade 1, 2 or 3) were identified. All subjects had full-limb radiographs analysed using the Osteotomy module within Medicad
resultsIndividual alignment variable were associated with both valgus and varus alignment (mechanical Lateral Distal Femoral Angle, Medial Proximal Tibial Angle and mechanical Lateral Distal Tibial Angle). Only the Medial Proximal Tibial Angle was significantly associated with structural progression and none of the variables was associated with symptom progression. The odds of joint space narrowing progression in the medial compartment occurring at 24 months increased by 21% for every one degree decrease (more varus) in Medial Proximal Tibial Angle (p < 0.001)
conclusionsOur results suggest that the risk of structural progression in the medial compartment is associated with greater varus alignment of the proximal tibia. LEVEL OF EVIDENCE: Level III, retrospective cohort study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.