Evidence map›Paper›PMID 31965145›Full record

ArticleInternational journal of epidemiology2020

Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis.

Shailja C Shah, Paolo Boffetta, Kenneth C Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, David Zaridze and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis.International journal of hygiene and environmental health · 2025
    Article
  5. Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.Journal of occupational medicine and toxicology (London, England) · 2025
    Review
  6. The global gastric cancer consortium: an update from the Stomach cancer Pooling (StoP) project.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 12 institutions in 6 countries.

Shailja C ShahGastroenterology, Hepatology and Nutrition, Vanderbilt University School of Medicine, Nashville, TN, USA.
Paolo BoffettaTisch Cancer Institute, Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kenneth C JohnsonSchool of Epidemiology and Public Health, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Jinfu HuHarbin Medical University, Harbin, China.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
Monica FerraroniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Japan.
Gerson Shigueaki HamadaNikkei Disease Prevention Center, São Paulo, Brazil.
Akihisa HidakaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Japan.
David ZaridzeDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
Dmitry MaximovichDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
Jesus VioqueCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Eva M Navarrete-MunozCIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Lina MuDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Stefania BocciaFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Roberta PastorinoSection of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Roma, Italy.
Robert C KurtzDepartment of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.
Matteo RotaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Rossella BonziDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Eva NegriDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Claudio PelucchiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dana HashimTisch Cancer Institute, Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
University of Milan · ITIcahn School of Medicine at Mount Sinai · USRussian Cancer Research Center NN Blokhin · RUUniversità Cattolica del Sacro Cuore · ITUniversitat de Miguel Hernández d'Elx · ESHarbin Medical University · CNMemorial Sloan Kettering Cancer Center · USPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUCLA Health · USUniversity at Buffalo, State University of New York · USUniversity of Ottawa · CAVanderbilt University · US

Funding

Learning Health System Scholar Program at VanderbiltK12HS026395 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROTHMAN, RUSSELL L., ROUMIE, CHRISTIANNE L. · 2018 to 2022
$2.7M
AHRQ HHS K12 HS026395
6 · The paper itself

Abstract

backgroundGastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. Our primary aim was to determine the association between occupations/occupational exposures and odds of gastric cancer.

methodsWe conducted a pooled-analysis of individual-level data harmonized from 11 studies in the Stomach cancer Pooling Project. Multivariable logistic regression was used to estimate the odds ratio (OR) of gastric cancer adjusted for relevant confounders.

resultsA total of 5279 gastric cancer cases and 12 297 controls were analysed. There were higher odds of gastric cancer among labour-related occupations, including: agricultural and animal husbandry workers [odds ratio (OR) 1.33, 95% confidence interval (CI): 1.06-1.68]; miners, quarrymen, well-drillers and related workers (OR 1.70, 95% CI: 1.01-2.88); blacksmiths, toolmakers and machine-tool operators (OR 1.41, 95% CI: 1.05-1.89); bricklayers, carpenters and construction workers (OR 1.30, 95% CI: 1.06-1.60); and stationary engine and related equipment operators (OR 6.53, 95% CI: 1.41-30.19). The ORs for wood-dust exposure were 1.51 (95% CI: 1.01-2.26) for intestinal-type and 2.52 (95% CI: 1.46-4.33) for diffuse-type gastric cancer. Corresponding values for aromatic amine exposure were 1.83 (95% CI: 1.09-3.06) and 2.92 (95% CI: 1.36-6.26). Exposure to coal derivatives, pesticides/herbicides, chromium, radiation and magnetic fields were associated with higher odds of diffuse-type, but not intestinal-type gastric cancer.

conclusionsBased on a large pooled analysis, we identified several occupations and related exposures that are associated with elevated odds of gastric cancer. These findings have potential implications for risk attenuation and could be used to direct investigations evaluating the impact of targeted gastric cancer prevention/early detection programmes based on occupation.

Indexed as

Occupational DiseasesOccupational ExposureStomach NeoplasmsHumansOdds Ratiodigestive system neoplasmenvironment and public healthepidemiologyGastric neoplasm

Identifiers

PMID31965145
PMCPMC10507679
OpenAlexW3001829699

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.