Evidence map›Paper›PMID 31964902›Full record

ArticleScientific reports2020

Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).

Manuel Fischer, Mirko Joppe, Barbara Mulinacci, Ronnald Vollrath, Kosta Konstantinidis, Peter Kötter, Luciano Ciccarelli, Janet Vonck, Dieter Oesterhelt, Martin Grininger

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Manuel FischerInstitute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Mirko JoppeInstitute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany.
Barbara MulinacciDepartment of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.
Ronnald VollrathDepartment of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.
Kosta KonstantinidisDepartment of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.
Peter KötterInstitute of Molecular Genetics and Cellular Microbiology, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-4666-4609
Luciano CiccarelliDepartment of Structural Biology, Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438, Frankfurt am Main, Germany.
Janet VonckDepartment of Structural Biology, Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438, Frankfurt am Main, Germany.
Dieter OesterheltDepartment of Membrane Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.
Martin GriningerInstitute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany. grininger@chemie.uni-frankfurt.de.ORCID http://orcid.org/0000-0002-7269-0667
Goethe University Frankfurt · DEMax Planck Institute of Biochemistry · DEMax Planck Institute of Biophysics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The yeast fatty acid synthase (FAS) is a barrel-shaped 2.6 MDa complex. Upon barrel-formation, two multidomain subunits, each more than 200 kDa large, intertwine to form a heterododecameric complex that buries 170,000 Å

Indexed as

Acyl Carrier ProteinFatty Acid SynthasesMultienzyme ComplexesProtein BiosynthesisProtein ConformationProtein DomainsProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcyl Carrier ProteinFAS1 protein, S cerevisiaeFAS2 protein, S cerevisiaeFatty Acid SynthasesMultienzyme ComplexesSaccharomyces cerevisiae Proteins

Identifiers

PMID31964902
PMCPMC6972935
OpenAlexW3002063846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.