ArticleNature communications2020
Alloying design of biodegradable zinc as promising bone implants for load-bearing applications.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.
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Who cites it
172 citing papers in PubMed, 706 citations in OpenAlex.
- Biodegradable molybdenum intramedullary nails facilitate fracture repair through neutrophil-mediated immune response.Materials today. Bio · 2026Article
- An osteogenesis mimicking biomineralized bone adhesive for rapid skeletal regeneration.Bioengineering & translational medicine · 2026Article
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Bone microenvironment-driven macro-galvanic coupling of Zn alloys: Mediating immune response and osteogenesis.Bioactive materials · 2026Article
- Mechanical Properties and Corrosion Behavior of Biodegradable Metals: Current Challenges.Materials (Basel, Switzerland) · 2026Review
- Ion-Driven Regulation of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Antibacterial and Immunomodulatory Coatings for Orthopedic Metal Implants: Biological Rationale, Design Strategies, and Translational Challenges.Advanced healthcare materials · 2026Review
- Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Bamboo-Like Whiskers-Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type-H Vessels and Osteoinduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tailoring the microstructure of biodegradable Zn-Cu-Li wires via thermo-mechanical processing towards high-performance surgical staples.Bioactive materials · 2026Article
- Rare-Earth modified biodegradable Zn alloys with high strength and enhanced osteogenesis.Nature communications · 2026Article
- Microinjection molded PLA/ZnO-TiORSC advances · 2026Article
- Biodegradable Metals and Corrosion Control: Challenges, Limits and New Opportunities for Innovating in Orthopedic Fixations.Materials (Basel, Switzerland) · 2026Review
- Environment-dependent degradation pathways of pure zinc induced by acid-alkali surface chemistry.RSC advances · 2026Article
- TZM Mo alloy behaves superb as biodegradable metal for bone-fracture healing intramedullary nail implant.Materials today. Bio · 2026Article
- Comparative Wear Evaluation of Pure Zn, Zn-Mg and Zn-Mg-Y Alloys Using Mass Loss Measurements and Optical Profilometry.Materials (Basel, Switzerland) · 2026Article
- Low addition of Er and Zn into biomedical magnesium with enhanced integrated properties for orthopedic applications:Bioactive materials · 2026Article
- A thermogalvanic cell dressing for smart wound monitoring and accelerated healing.Nature biomedical engineering · 2026Article
- Effect of Heat Treatment on Microstructural Evolution, Mechanical Properties, and Degradation Behavior of Zn-3Mg Alloy Fabricated by Laser Additive Manufacturing.Micromachines · 2025Article
- Developing 400 MPa grade biodegradable Zn alloys with superior osteogenic and antibacterial performance.Scientific reports · 2025Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies. Li exhibits the most effective strengthening role in Zn, followed by Mg. Alloying leads to accelerated degradation, but adequate mechanical integrity can be expected for Zn alloys when considering bone fracture healing. Adding elements Mg, Ca, Sr and Li into Zn can improve the cytocompatibility, osteogenesis, and osseointegration. Further optimization of the ternary Zn-Li alloy system results in Zn-0.8Li-0.4Mg alloy with the ultimate tensile strength 646.69 ± 12.79 MPa and Zn-0.8Li-0.8Mn alloy with elongation 103.27 ± 20%. In summary, biocompatible Zn-based BMs with strength close to pure Ti are promising candidates in orthopedics for load-bearing applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.