Evidence map›Paper›PMID 31964836›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

CagA-ASPP2 complex mediates loss of cell polarity and favors

Ludovico Buti, Carlos Ruiz-Puig, Dennis Sangberg, Thomas M Leissing, R Camille Brewer, Richard P Owen, Bruno Sgromo, Christophe Royer, Daniel Ebner, Xin Lu

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 54 citations in OpenAlex.

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  7. Pathogenicity ofWorld journal of clinical oncology · 2025
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  10. Organoids in cancer therapies: a comprehensive review.Frontiers in bioengineering and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ludovico ButiLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom; ludovico.buti@crl.com xin.lu@ludwig.ox.ac.uk.ORCID 0000-0002-0235-588X
Carlos Ruiz-PuigLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Dennis SangbergLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Thomas M LeissingLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
R Camille BrewerLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Richard P OwenLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Bruno SgromoDepartment of Surgery, Churchill Hospital, Oxford University Hospitals, Oxford OX3 7LJ, United Kingdom.
Christophe RoyerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom.
Daniel EbnerTarget Discovery Institute, University of Oxford, Oxford OX3 7FZ, United Kingdom.
Xin LuLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom; ludovico.buti@crl.com xin.lu@ludwig.ox.ac.uk.ORCID 0000-0002-6587-1152
University of Oxford · GBChurchill Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main risk factor for stomach cancer, the third most common cause of cancer death worldwide, is infection with

Indexed as

Antigens, BacterialApoptosis Regulatory ProteinsBacterial ProteinsEpithelial CellsHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansOrganoidsProtein BindingStomachAntigens, BacterialApoptosis Regulatory ProteinsBacterial ProteinscagA protein, Helicobacter pyloriTP53BP2 protein, humancell polaritymicrobial pathogenesistumor suppressors

Identifiers

PMID31964836
PMCPMC7007547
OpenAlexW2998250341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.