ArticleProceedings of the National Academy of Sciences of the United States of America2020
Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications.Journal of neurochemistry · 2025Review
- Local thalamic interneurons drive spindle termination and enable sleep-dependent learning.bioRxiv : the preprint server for biology · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Retinal ganglion cell circuits and glial interactions in humans and mice.Trends in neurosciences · 2024Review
- Retinal Input Is Required for the Maintenance of Neuronal Laminae in the Ventrolateral Geniculate Nucleus.eNeuro · 2024Article
- A novel developmental critical period of orexinergic signaling in the primary visual thalamus.iScience · 2024Article
- Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.Neural development · 2024Article
- Astrocytes: Lessons Learned from the Cuprizone Model.International journal of molecular sciences · 2023Review
- Enhancement and contextual modulation of visuospatial processing by thalamocollicular projections from ventral lateral geniculate nucleus.Nature communications · 2023Article
- Developmental Expression of the Cell Cycle Regulator p16The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus.eLife · 2022Article
- Cre driver mouse lines for thalamocortical circuit mapping.The Journal of comparative neurology · 2022Article
- Development of astrocyte morphology and function in mouse visual thalamus.The Journal of comparative neurology · 2022Article
- Characterization of Macular Structural and Microvascular Changes in Thalamic Infarction Patients: A Swept-Source Optical Coherence Tomography-Angiography Study.Brain sciences · 2022Article
- Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex.Frontiers in neural circuits · 2022Review
- Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus.Journal of neurochemistry · 2021Article
- Migratory cortical interneuron-specific transcriptome abnormalities in schizophrenia.Journal of psychiatric research · 2021Article
- Widespread Decoding of Tactile Input Patterns Among Thalamic Neurons.Frontiers in systems neuroscience · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Inhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early development, these interneurons undergo long-range migration from germinal zones, a process regulated by the innervation of the visual thalamus by retinal ganglion cells. Here, using transcriptomic approaches, we identified a motogenic cue, fibroblast growth factor 15 (FGF15), whose expression in the visual thalamus is regulated by retinal input. Targeted deletion of functional FGF15 in mice led to a reduction in thalamic GABAergic interneurons similar to that observed in the absence of retinal input. This loss may be attributed, at least in part, to misrouting of interneurons into nonvisual thalamic nuclei. Unexpectedly, expression analysis revealed that FGF15 is generated by thalamic astrocytes and not retino-recipient neurons. Thus, these data show that retinal inputs signal through astrocytes to direct the long-range recruitment of interneurons into the visual thalamus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.