ArticleProceedings of the National Academy of Sciences of the United States of America2020
Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 94 citations in OpenAlex.
- Biomimetic nanocages with cascade homing for theranostics of ischemia-reperfusion acute kidney injury.Materials today. Bio · 2026Article
- Proton wave propagation along collagen fibers.European biophysics journal : EBJ · 2026Article
- Linking cellular metabolism to mitochondrial outer membrane potential.Mitochondrion · 2026Article
- Profiling of Yeast Saccharomyces cerevisiae Mitochondrial AMPylome Reveals a Regulation of OXPHOS Coupling through ATP Synthase Subunit Delta.Journal of proteome research · 2026Article
- Mitochondrial Cristae as Separate Compartments: Linking Organization and Function.Current issues in molecular biology · 2026Review
- Cristae: bridging bioenergetic hubs and compartmental barriers in mitochondrial homeostasis.Cell death & disease · 2026Review
- Acid-Base Dysregulation Links Aging Metabolism to Frailty.Aging cell · 2026Article
- The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria.Protein science : a publication of the Protein Society · 2026Review
- ATP synthase activity boosts membrane proton acceptance and lateral diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bee Venom Proteins Enhance Proton Absorption by Membranes Composed of Phospholipids of the Myelin Sheath and Endoplasmic Reticulum: Pharmacological Relevance.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers.Communications chemistry · 2025Article
- Calculation of proton transmembrane-electrostatic interaction force and elucidation of the water droplet experiment with a transient protonic front.RSC advances · 2025Article
- Mitochondrial hyperactivity and reactive oxygen species drive innate immunity to the yellow fever virus-17D live-attenuated vaccine.PLoS pathogens · 2025Article
- Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion.Biological reviews of the Cambridge Philosophical Society · 2025Review
- A splendid molecular factory: De- and reconstruction of the mammalian respiratory chain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Modulating Liposome Surface Charge for Maximized ATP Regeneration in Synthetic Nanovesicles.ACS synthetic biology · 2024Article
- EARLY NODULIN93 acts via cytochrome c oxidase to alter respiratory ATP production and root growth in plants.The Plant cell · 2024Article
- Chloroplast ATP synthase: From structure to engineering.The Plant cell · 2024Review
- piRNAs are regulators of metabolic reprogramming in stem cells.Nature communications · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria have a characteristic ultrastructure with invaginations of the inner membrane called cristae that contain the protein complexes of the oxidative phosphorylation system. How this particular morphology of the respiratory membrane impacts energy conversion is currently unknown. One proposed role of cristae formation is to facilitate the establishment of local proton gradients to fuel ATP synthesis. Here, we determined the local pH values at defined sublocations within mitochondria of respiring yeast cells by fusing a pH-sensitive GFP to proteins residing in different mitochondrial subcompartments. Only a small proton gradient was detected over the inner membrane in wild type or cristae-lacking cells. Conversely, the obtained pH values did barely permit ATP synthesis in a reconstituted system containing purified yeast F
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