Evidence map›Paper›PMID 31964791›Full record

ArticleAntimicrobial agents and chemotherapy2020

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus.

Jickky Palmae Sarathy, Uday S Ganapathy, Matthew D Zimmerman, Véronique Dartois, Martin Gengenbacher, Thomas Dick

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Identification and characterization ofMicrobiology spectrum · 2026
    Article
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  5. Review
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  10. Review
  11. Review
  12. Toward better cures forClinical microbiology reviews · 2024
    Review
  13. TBAJ-587, a novel diarylquinoline, is active againstAntimicrobial agents and chemotherapy · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jickky Palmae SarathyDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Uday S GanapathyCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Matthew D ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9470-5009
Martin GengenbacherCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0208-5920
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA thomas.dick@hmh-cdi.org.ORCID 0000-0002-9604-9452
Seton Hall University · USHackensack Meridian Health · USNational University of Singapore · SG

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

Lung disease caused by

Indexed as

AnimalsAnti-Bacterial AgentsDiarylquinolinesDisease Models, AnimalFemaleHumansMice, SCIDMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousAnti-Bacterial AgentsbedaquilineDiarylquinolinesTBAJ-876bedaquilineMycobacterium abscessusnontuberculous mycobacteriaNTMTBAJ-876

Identifiers

PMID31964791
PMCPMC7179298
OpenAlexW3000474512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.