ArticleDevelopment (Cambridge, England)2020
Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation.
Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- TiFM2.0 - versatile mechanical measurement and actuation in live embryos.Development (Cambridge, England) · 2026Article
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- A mechanochemical model recapitulates distinct vertebrate gastrulation modes.Science advances · 2023Article
- Downregulation of extraembryonic tension controls body axis formation in avian embryos.Nature communications · 2023Article
- Article
- Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanical regulation of early vertebrate embryogenesis.Nature reviews. Molecular cell biology · 2022Review
- Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development.Frontiers in cell and developmental biology · 2021Article
- Cellular processes driving gastrulation in the avian embryo.Mechanisms of development · 2020Review
- Adaptive viscoelasticity of epithelial cell junctions: from models to methods.Current opinion in genetics & development · 2020Review
- Mechanosensitive Junction Remodeling Promotes Robust Epithelial Morphogenesis.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Directional cell intercalations of epithelial cells during gastrulation has, in several organisms, been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cytoskeleton and is postulated to reflect directional tension that drives oriented cell intercalations. We have characterised and applied a recently introduced non-destructive optical manipulation technique to measure the tension in individual epithelial cell junctions of cells in various locations and orientations in the epiblast of chick embryos in the early stages of primitive streak formation. Junctional tension of mesendoderm precursors in the epiblast is higher in junctions oriented in the direction of intercalation than in junctions oriented perpendicular to the direction of intercalation and higher than in junctions of other cells in the epiblast. The kinetic data fit best with a simple viscoelastic Maxwell model, and we find that junctional tension, and to a lesser extent viscoelastic relaxation time, are dependent on myosin activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.