Evidence map›Paper›PMID 31964763›Full record

ArticleJournal of lipid research2020

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.

Nadya M Morrow, Amy C Burke, Joshua P Samsoondar, Kyle E Seigel, Andrew Wang, Dawn E Telford, Brian G Sutherland, Conor O'Dwyer, Gregory R Steinberg, Morgan D Fullerton and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nadya M MorrowMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7.
Amy C BurkeMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7.
Joshua P SamsoondarMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7; Medicine,University of Western Ontario, London, Ontario, Canada N6A 5B7.
Kyle E SeigelMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7.
Andrew WangMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7.
Dawn E TelfordMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Medicine,University of Western Ontario, London, Ontario, Canada N6A 5B7.
Brian G SutherlandMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7.
Conor O'DwyerDepartment of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.
Gregory R SteinbergDivision of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8S 4K1.
Morgan D FullertonDepartment of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.
Murray W HuffMolecular Medicine, Robarts Research Institute,University of Western Ontario, London, Ontario, Canada N6A 5B7; Departments of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5B7; Medicine,University of Western Ontario, London, Ontario, Canada N6A 5B7.
Western University · CAUniversity of Ottawa · CAMcMaster University · CA

Funding

CIHR 201709FDNCEBA-116200CIHR MOP-126045CIHR PJT148634
6 · The paper itself

Abstract

Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions. The flavonoid nobiletin displays potent lipid-lowering and insulin-sensitizing properties in mice with metabolic dysfunction. However, the mechanisms by which nobiletin mediates metabolic protection are not clearly established. The central role of AMP-activated protein kinase (AMPK) as an energy sensor suggests that AMPK is a target of nobiletin. We tested the hypothesis that metabolic protection by nobiletin required phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in mouse hepatocytes, in mice deficient in hepatic AMPK (

Indexed as

AMP-Activated Protein KinasesAnimalsAntioxidantsCitrusDiet, High-FatFlavonesMaleMiceMice, Inbred C57BLMice, KnockoutProtective AgentsAMP-Activated Protein KinasesAntioxidantsFlavonesnobiletinProtective Agentsadenosine monophosphate-activated protein kinasefatty acid oxidationhypolipidemic drugsinsulin resistancelipogenesisobesitysteatohepatitis

Identifiers

PMID31964763
PMCPMC7053837
OpenAlexW3001857422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.