Evidence map›Paper›PMID 31964761›Full record

ArticleJournal of lipid research2020

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

Grace L Guo, John Y L Chiang

Abstract readComment
In one paragraph

Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
  2. Cholestasis in Alcohol-Associated Liver Disease.The American journal of pathology · 2026
    Review
  3. Muricholic acid mediates puberty initiation via the hypothalamic TGR5 signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Bile acids and their receptors in hepatic immunity.Liver research (Beijing, China) · 2025
    Review
  5. Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  6. Article
  7. Review
  8. Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
    Review
  9. Spaceflight alters host-gut microbiota interactions.NPJ biofilms and microbiomes · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Probiotics, prebiotics, and synbiotics in nonalcoholic fatty liver disease and alcohol-associated liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Grace L GuoDepartment of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854.
John Y L Chiang

Funding

TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Regulation of Bile Acid Synthesis by Nuclear ReceptorsR37DK058379 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI CHIANG, JOHN Y. L. · 2011 to 2020
$3.6M
Regulation of Bile Acid Synthesis by Nuclear ReceptorsR01DK058379 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI CHIANG, JOHN Y. L. · 2002 to 2010
$2.6M
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasisR01GM104037 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2013 to 2016
$1.1M
Differential roles of FXR and FGF15 in liver fibrosis developmentR21ES029258 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2018 to 2019
$426k
Role of Intestinal Bile Acid Signaling in Liver DiseasesI01BX002741 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI GRACE L GUO · 2018 to 2026
–
BLRD VA I01 BX002741NIDDK NIH HHS R01 DK058379NIDDK NIH HHS R37 DK058379NIEHS NIH HHS R21 ES029258NIEHS NIH HHS T32 ES007148NIGMS NIH HHS R01 GM104037
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BileBile Acids and SaltsAnimalsHumansLiverMiceSignal TransductionBile Acids and Salts

Identifiers

PMID31964761
PMCPMC7053840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.