Evidence map›Paper›PMID 31964746›Full record

ArticleInfection and immunity2020

Antibiotic Degradation by Commensal Microbes Shields Pathogens.

Mergim Gjonbalaj, James W Keith, Mytrang H Do, Tobias M Hohl, Eric G Pamer, Simone Becattini

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Oral and plasma microbiome in the context of acute febrile illness.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Review
  4. Review
  5. Listeriosis.Nature reviews. Disease primers · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Antibiotic resistance spectrums ofFrontiers in veterinary science · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mergim GjonbalajImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
James W KeithImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mytrang H DoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Tobias M HohlImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Eric G PamerImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Simone BecattiniImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA becattis@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · USMemorial Hospital · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant PathogensU01AI124275 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI PAMER, ERIC G., XAVIER, JOAO · 2016 to 2020
$8.9M
TNF Mediated Immune Defense Against Listeria InfectionR01AI042135 · NIAID · YALE UNIVERSITY · PI PAMER, ERIC G. · 1998 to 2019
$7.3M
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI042135NIAID NIH HHS U01 AI124275
6 · The paper itself

Abstract

The complex bacterial populations that constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those encoding β-lactamase enzymes (BLA), which degrade commonly prescribed antibiotics such as ampicillin. The prevalence of such genes in commensal bacteria has been increased in recent years by the wide use of antibiotics in human populations and in livestock. While transfer of ARGs between bacterial species has well-established dramatic public health implications, these genes can also function in

Indexed as

AmpicillinAnimalsAnti-Bacterial Agentsbeta-LactamasesClostridioides difficileDrug Resistance, BacterialEscherichia coliHydrolysisIntestinesListeria monocytogenesMiceMicrobial InteractionsMicrobial ViabilityAmpicillinAnti-Bacterial Agentsbeta-Lactamasesantibiotic resistancegut microbiotainfection

Identifiers

PMID31964746
PMCPMC7093146
OpenAlexW3001085047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.