ArticlemBio2020
Gut Feelings Begin in Childhood: the Gut Metagenome Correlates with Early Environment, Caregiving, and Behavior.
Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Socioeconomic position and the gut microbiota: a narrative synthesis of the association and recommendations.Gut microbes · 2026Pooled it
- The Gut Microbiome in Early Life Stress: A Systematic Review.Nutrients · 2023Pooled it
- The development of the gut microbiome and temperament during infancy and early childhood: A systematic review.Developmental psychobiology · 2022Pooled it
- A randomized controlled trial of environmental richness on gastrointestinal symptoms, salivary cortisol, and gut microbiota in early childhood.Scientific reports · 2025Trial
- Family Anthropometric and Physiological Correlations With Parent- and Teacher-Rated Preschooler Socio-Behavioral Health.Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2026Article
- The relationship between the gut microbiota and neuropsychological development and behaviour during childhood and adolescence: a systematic review of epidemiological studies.Brain, behavior, & immunity - health · 2026Review
- Review
- The Gut Microbiome and Its Impact on Mood and Decision-Making: A Mechanistic and Therapeutic Review.Nutrients · 2025Review
- QIIME2 enhances multi-amplicon sequencing data analysis: a standardized and validated open-source pipeline for comprehensive 16S rRNA gene profiling.Microbiology spectrum · 2025Article
- Postpartum Maternal Stress is Unrelated to the Infant Fecal Microbiome, but is Associated With the Human Milk Microbiome in Exclusively Breastfeeding Mother-Infant Dyads: The Mother-Infant Microbiomes, Behavior, and Ecology Study (MIMBES).American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships.Reviews in cardiovascular medicine · 2025Review
- Associations between relative abundances ofFrontiers in microbiology · 2025Article
- The associations between gut microbiota and fecal metabolites with intelligence quotient in preschoolers.BMC microbiology · 2024Article
- Altered Gut Microbiota Patterns in Young Children with Recent Maltreatment Exposure.Biomolecules · 2024Article
- Transgenerational effects of early life stress on the fecal microbiota in mice.Communications biology · 2024Article
- Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children.Microbiome · 2024Article
- Long-Term Impact of Childhood Adversity on the Gut Microbiome of Nursing Students.International journal of environmental research and public health · 2024Article
- The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence.Current neuropharmacology · 2024Review
- Adverse childhood experience and depression: the role of gut microbiota.Frontiers in psychiatry · 2024Review
- Association of Probable Post-Traumatic Stress Disorder with Dietary Pattern and Gut Microbiome in a Cohort of Women.Nature. Mental health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Psychosocial environments impact normative behavioral development in children, increasing the risk of problem behaviors and psychiatric disorders across the life span. Converging evidence demonstrates that early normative development is affected by the gut microbiome, which itself can be altered by early psychosocial environments. However, much of our understanding of the gut microbiome's role in early development stems from nonhuman animal models and predominately focuses on the first years of life, during peri- and postnatal microbial colonization. As a first step to identify if these findings translate to humans and the extent to which these relationships are maintained after initial microbial colonization, we conducted a metagenomic investigation among a cross-sectional sample of early school-aged children with a range of adverse experiences and caregiver stressors and relationships. Our results indicate that the taxonomic and functional composition of the gut microbiome correlates with behavior during a critical period of child development. Furthermore, our analysis reveals that both socioeconomic risk exposure and child behaviors associate with the relative abundances of specific taxa (e.g.,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.